Doorka Dhaqdhaqaaqa Nrf2

Daraasado badan oo cilmi baaris ah oo hadda socda oo ku saabsan kansarka ayaa u oggolaaday xirfadlayaasha caafimaadka inay fahmaan habka jirku u nadiifiyo. Iyadoo la falanqeynayo hiddo-wadaha kor loo qaaday ee unugyada burooyinka, cilmi-baarayaashu waxay ogaadeen nukliyeerka erythroid-ka 2-xariirka 2 ee dariiqa calaamadaynta, oo loo yaqaan Nrf2. NRF2 waa cunsur qoraal oo muhiim ah kaas oo dhaqaajiya jirka bini'aadamka hababka antioxidant ilaalinta si loo xakameeyo oksaydhka ee ka imanaya arrimaha dibadda iyo gudaha labadaba si looga hortago heerarka korodhka cadaadiska oksaydhka.

Mabaadi'da Nrf2

NRF2 waxay lama huraan u tahay ilaalinta guud ahaan caafimaadka iyo fayoobaanta sababtoo ah waxay u adeegtaa ujeedada aasaasiga ah ee nidaaminta sida aan u maareyno wax kasta oo aan la kulanno maalin kasta oo aynaan jirran. Firfircoonida NRF2 waxay door ka ciyaartaa wajiga II nidaamka sun-saaridda. ee wajiga I.

Dhaqdhaqaaqa NRF2 wuxuu yareeyaa oksaydhka guud iyo bararka jidhka bini'aadamka iyada oo loo marayo saameynta hormetic. Si loo kiciyo NRF2, falcelin barar ah oo ay sababto oksaydhisku waa inay dhacaan si unugyadu u soo saaraan jawaab celin la qabsi ah oo ay abuuraan antioxidants, sida glutathione. Si loo burburiyo mabda'a Nrf2, asal ahaan, diiqada oksaydhku waxay kicisaa NRF2 taas oo markaa kicisa jawaabta antioxidant ee jidhka bini'aadamka. NRF2 waxay u shaqeysaa si ay u dheelitirto calaamadaha redox, ama dheellitirka oxidant iyo heerarka antioxidant ee unugyada.

Tilmaan weyn oo ku saabsan sida habkani u shaqeeyo ayaa lagu muujin karaa jimicsi. Inta lagu guda jiro jimicsi kasta, muruqa ayaa la qabsanaya si uu u habeeyo fadhi jimicsi kale. Haddii NRF2 ay hoos u dhacdo ama aad u muujiso sababtoo ah caabuqyada joogtada ah ama korodhka sunta, taas oo laga yaabo in lagu arko bukaanada qaba xanuunka jawaab-celinta bararka ee daba-dheeraada, ama CIRS, arrimaha caafimaadku way ka sii dari karaan ka dib dhaqdhaqaaqa NRF2. Iskusoo wada duuboo, haddii DJ-1 uu noqdo mid aad u-oxidized, NRF2 firfircoonidu si dhakhso ah ayey u dhammaan doontaa.

Saamaynta NRF2 Dhaqdhaqaaqa

Dhaqdhaqaaqa NRF2 ayaa si weyn loogu muujiyaa sambabada, beerka, iyo kelyaha. Nukliyeerka erythroid 2 ee la xidhiidha 2, ama NRF2, inta badan waxay u shaqeysaa iyada oo ka hortagaysa heerarka korodhka oksaydhka ee jidhka bini'aadamka taas oo u horseedi karta cadaadiska oksaydhka. Dhaqdhaqaaqa Nrf2 wuxuu kaa caawin karaa daaweynta arrimo caafimaad oo kala duwan, si kastaba ha ahaatee, firfircoonida dheeraadka ah ee Nrf2 waxay ka sii dari kartaa dhibaatooyin kala duwan, kuwaas oo hoos lagu muujiyey.

Firfircoonida joogtada ah ee Nrf2 ayaa ku caawin karta:

• Gabow (ie Cimri dheer)
• Is-difaaca jirka iyo bararka guud (ie Arthritis, Ootisamka)
• Kansarka iyo Ka-hortagga Kiimikada (ie EMF Exposure)
• Niyad-jabka iyo Walaaca (sida PTSD)
• Soo-gaadhista daroogada (khamriga, NSAIDs)
• Jimicsiga iyo Waxqabadka Adkeysiga
• Cudurka mindhicirka (sida SIBO, dysbiosis, colitis boog)
• Cudurka kelyaha (ie, dhaawaca kelyaha oo ba'an, cudur kelyaha raaga, Lupus nephritis)
• Cudurka Beerka (sida Cudurka Beerka ee Khamriga, Cagaarshowga Ba'an, Cudur Beerka Dufanka leh ee Aan Khamriga ahayn, Steatohepatitis aan Khamriga ahayn, Cirrhosis)
• Cudurka Sambabada (sida Neefta, Fibrosis)
• Cudurka dheef-shiid kiimikaadka iyo xididdada dhiigga (ie Atherosclerosis, hypertension, Stroke, diabetes)
• Neurodegeneration (sida Alzheimers, Parkinson's, Huntington's iyo ALS)
• Xanuun (sida Neuropathy)
• Xanuunada Maqaarka (ie Psoriasis, UVB/Sun Protection)
• Soo-gaadhista sunta (Arsenic, Asbestos, Cadmium, Fluoride, Glyphosate, Mercury, Sepsis, qiiq)
• Aragga (ie, Iftiin iftiimaya, Dareenka, Cataract, Dystrophy Corneal)

Dhaqdhaqaaqa Nrf2 ayaa ka sii dari kara:

• Atherosclerosis
• Kansarka (sida Maskaxda, Naaska, Madaxa, Qoorta Pancreatic, Prostate, Beerka, Thyroid)
• Cudurka Ka-jawaabista Caabuqa ee Daba-dheeraada (CIRS)
• Ku-tallaalidda Wadnaha (inta ay furan tahay NRF2 waxay noqon kartaa mid xun, NRF2 waxay kaa caawin kartaa hagaajinta)
• hepatitis C
• Nephritis (xaalad daran)
• Vitiligo

Intaa waxaa dheer, NRF2 waxay kaa caawin kartaa samaynta kaabayaasha nafaqeynta ee gaarka ah, daawooyinka, iyo daawooyinka shaqeeyaan. Kaabyaal badan oo dabiici ah ayaa sidoo kale kaa caawin kara kicinta NRF2. Iyada oo loo marayo daraasadaha cilmi-baarista ee hadda, cilmi-baarayaashu waxay muujiyeen in tiro badan oo ka mid ah xeryahooda oo mar la rumeysan yahay inay yihiin antioxidants ay runtii yihiin pro-oxidants. Taasi waa sababtoo ah ku dhawaad ​​dhamaantood waxay u baahan yihiin NRF2 si ay u shaqeeyaan, xitaa kaabis sida curcumin iyo saliidda kalluunka. Kookaha, tusaale ahaan, waxaa la tusay inay dhaliso saamaynta antioxidant ee jiirarka kuwaas oo leh hidda-wadaha NRF2.

Siyaabaha Loo Hawlgeliyo NRF2

Xaaladda cudurrada neerfayaasha sida cudurka Alzheimers, cudurka Parkinson, istaroogga ama xitaa cudurrada difaaca jirka, waxay u badan tahay inay ugu fiican tahay in Nrf2 la hagaajiyo, laakiin qaabka hormoonnada. Isku-darka firfircoonayaasha NRF2 ayaa sidoo kale laga yaabaa inay yeeshaan wax lagu daro ama saameyn isku-dhafan, maadaama ay marmar ku xiran tahay qiyaasta. Siyaabaha ugu sarreeya ee lagu kordhiyo muujinta Nrf2 ayaa ku taxan hoos:

• HIST (Jimicsi) + CoQ10 + Qorrax (kuwaani aad bay u wada shaqeeyaan)
• Brokoli sprouts + LLLT madaxa iyo mindhicirka
• Butyrate + Super Coffee + Qorraxda Subaxda
• Acupuncture (tani waa hab kale, acupuncture laser sidoo kale waa la isticmaali karaa)
• Soonka
• Cannabidiol (CBD)
• Mane libaax + Melatonin
• Alfa-lipoic acid + DIM
• Qadhaadh
• Dhaqdhaqaaqa PPAR-gamma

Liistada soo socota ee dhamaystiran oo ka kooban in ka badan 350 siyaabo kale oo lagu dhaqaajiyo Nrf2 iyada oo loo marayo cuntada, qaab nololeedka iyo qalabka, probiotics, supplements, geedo iyo saliid, hormoonnada iyo neurotransmitters, daroogooyinka / daawooyinka iyo kiimikooyinka, waddooyinka / qoraallada, iyo sidoo kale siyaabo kale, waa kaliya hage kooban oo ku saabsan waxa kicin kara Nrf2. Si kooban oo maqaalkan ah, waxaan uga tagnay in ka badan 500 oo cuntooyin kale ah, kaabyaal nafaqo iyo iskudhis kuwaas oo gacan ka geysan kara dhaqaajinta Nrf2. Kuwa soo socda ayaa ku taxan:

Cuntada:

• Acai Berries
• Khamriga (khamriga cas waa ka fiican yahay, gaar ahaan haddii uu jiro guf ku jira, sida protocatechuic aldehyde oo ka soo jeeda corks sidoo kale waxay dhaqaajin kartaa NRF2. Guud ahaan, khamriga laguma talinayo, inkastoo qaadashada degdega ah ay kordhiso NRF2. Qaadashada joogtada ah ayaa laga yaabaa inay hoos u dhigto NRF2.
• Algae (kelp)
• tufaax
• Shaaha Madow
• Brazil Nuts
• Broccoli sprouts (iyo isothiocyanates kale, sulforaphane iyo sidoo kale khudaarta cruciferous sida bok choy oo leh D3T)
• Blueberries (0.6-10 g/maalintii)
• Karootada (falcarinone)
• Basbaaska Cayenne (Capsaicin)
• Seleri (Butylphthalide)
• Chaga (Betulin)
• Chamomile Cha
• chia
• Baradhada Shiinaha
• Chokeberry (Aronia)
• Shukulaatada (Madaw ama kookaha)
• Qoraxda
• Qaxwaha (sida chlorogenic acid, Cafestol iyo Kahweol)
• Cordyceps
• Kalluunka (iyo Shellfish)
• Flaxseed
• Garlic
• Ghee (laga yaabo)
• Ginger (iyo Cardamonin)
• Gojiberries
• Canab (Naringenin - 50 mg/kg/d naringenin)
• Canab
• Shaah cagaaran
• dhafeen,
• Wadnaha Timirta
• Xijiki/Wakame
• malabkii
• Kiwi
• Digsiyada
• Lione Mane
• Mahuwa
• Mangos (Mangiferin)
• mangosteen
• Caano (ri, lo'da - iyada oo loo marayo nidaaminta microbiome)
• Mulderey
• Saliid saytuun ah (pomace - hydroxytyrosol iyo Oleanolic acid)
• Omega 6 Fatty Acids (Lipoxin A4)
• Osange Oranges (Morin)
• Mushrooms Oyster
• babaygu
• lawska
• Roodhadhka Beeraha
• rummaanka (Punicalagin, Ellagic Acid)
• Propolis (Pinocembrin)
• Baradhada macaan ee guduudan
• Rambutan (Geraniin)
• Basasha
• Reishi
• Rhodiola Rosea (Salidroside)
• Bariiska Bariiska (cycloartenyl ferulate)
• Riceberry
• Rooibos shaaha
• Rosemary
• Sage
• Safflower
• Saliida Saliidda
• Soy (iyo isoflavones, Daidzein, Genistein)
• squash
• strawberries
• Tartary Buckwheat
• milix
• Tamaandho
• Tonka digirta
• timirta
• Wasabi
• Qaraha

Hab-nololeedka iyo Qalabka:

• Acupuncture iyo Electroacupuncture (iyada oo loo marayo kolajka cascade ee ECM)
• Iftiinka buluuga ah
• Ciyaaraha Maskaxda (waxay ku kordhisaa NRF2 gudaha hippocampus)
• Xaddidaadda Xaddidaadda
• Qabow (qubeyska, qulqulka, qubeyska barafka, qalabka, cryotheraphy)
• EMFs (soo noqnoqoshada hooseeya, sida PEMF)
• Jimicsi (Jimicsi degdeg ah sida HIST ama HIIT waxay u muuqataa inay faa'iido badan u leedahay kicinta NRF2, halka jimicsiga dheer uusan kicin NRF2, laakiin wuxuu kordhiyaa heerarka glutathione)
• Cunto dufan badan (cunto)
• Kuleylka Sare (Sauna)
• Neefsashada Haydaroojiinka iyo Biyaha Hydrogen
• Daaweynta Oxygen ee Hyperbaric
• Daaweynta Infrared (sida Joovv)
• Faytamiin C ee xididdada dhiigga
• Ketogenic Cunto
• Ozone
• Sigaar cabista (lama talin - sigaar cabbiddu waxay kordhisaa NRF2, sigaar cabbintu waxay hoos u dhigtaa NRF2. Haddii aad doorato inaad sigaar cabto, Basil Quduuska ah ayaa kaa caawin kara hoos u dhigista NRF2)
• Qorraxda (UVB iyo Infrared)

Probiotics:

• Bacillus subtilis (fmbJ)
• Clostridium butyricum (MIYAIRI 588)
• Lactobacillus brevis
• Lactobacillus casei (SC4 iyo 114001)
• Lactobacillus collinoides
• Lactobacillus gasseri (OLL2809, L13-Ia, iyo SBT2055)
• Lactobacillus helveticus (NS8)
• Lactobacillus paracasei (NTU 101)
• Lactobacillus plantarum (C88, CAI6, FC225, SC4)
• Lactobacillus rhamnosus (GG)

Kaabayaasha, Dhirta, iyo Saliidda:

• Acetyl-L-Carnitine (ALCAR) iyo Carnitine
• Allicin
• Alfa-lipoic acid
• Amentoflavone
• Jaalliyadaha xagjirnimada
• Agmatine
• Apigenin
• Arginine
• Artichoke (Cyanropicrin)
• Ashwagen
• Astragalus
• Bacopa
• Beefsteak (Isogemaketone)
• Berberine
• Beta-caryophyllene
• Bidens Pilosa
• Saliidda xabka madow (Thymoquinone)
• Boswellia
• Butein
• Butyrate
• Cannabidiol (CBD)
• Carotenioids (sida Beta-carotene [synergy with Lycopene – 2 � 15 mg/d lycopene], Fucoxanthin, Zeaxanthin, Astaxanthin, iyo Lutein)
• Chitrak
• Chlorella
• Chlorophyll
• Chrysanthemum zawadskii
• Cinnamomea
• Sundew Common
• copper
• Coptis
• CoQ10
• Curcumin
• Damiana
• Dan Shen/Sage Cas (Miltrone)
• DIM
• Dioscin
• Dong Ling Cao
• Dong Quai (ginseng dheddig)
• Ecklonia Cava
• EGCG
• Elecampane / Inula
• Eucommia Bark
• Ferulic Acid
• Fisetin
• Saliidda Kalluunka (DHA/EPA - 3 � 1 g/d saliid kalluunka ka kooban 1098 mg EPA iyo 549 mg DHA)
• Galangal
• Gastrodin (Tian Ma)
• Gentian
• Geranium
• Ginkgo Biloba (Ginkgolide B)
• Glasswort
• Gotu Kola
• Beeraha canabkiisa
• Timo-timo
• Haritaki (Triphala)
• Hawthorn
• Helichrysum
• Henna (Juglone)
• Hibiscus
• Higenamine
• Basil Quduuska ah/Tulsi (Ursolic acid)
• Hops
• Weed Ari Horny (Icariin/Icariside)
• Indigo Naturalis
• Birta (lama talinayo ilaa lama huraan)
• I3C
• Oohintii Ayuub
• Moringa Oleifera (sida Kaempferol)
• Inchinkoto (combo of Zhi Zi iyo Wormwood)
• Xididka Kudzu
• Root-shubka
• Lindera Root
• Luteolin (Qiyaas sare oo loogu talagalay firfircoonida, qiyaaso hoose ayaa ka hortagaya NRF2 kansarka inkastoo)
• Magnolia
• Manjistha
• Maximowiczianum (Acerogenin A)
• Arnica Mexico
• Caanaha Thistle
• MitoQ
• Mu Xiang
• Mucuna Pruriens
• Nikotinamide iyo NAD+
• Panax Ginseng
• Ubaxa xamaasadda leh (sida Chrysin, laakiin chyrisin waxa kale oo laga yaabaa inay yarayso NRF2 iyada oo loo marayo hab-dhisidda calaamadaha PI3K/Akt)
• Pau d'arco (Lapacho)
• Phoretin
• Piceatannol
• PQQ
• Procyanidin
• Pterostilbene
• pueraria
• Quercetin (qiyaas sare oo keliya, qiyaaso hoose ayaa xakameynaya NRF2)
• Qiang Huo
• Red Clover
• Resveratrol (Piceid iyo phytoestrogens kale oo asal ahaan, Knotweed)
• Rose Hips
• Rosewood
• Rutin
• Sappanwood
• Sarsaparilla
• Saururus chinensis
• SC-E1 (Gypsum, Jasmine, Licorice, Kudzu, iyo Ubax Balloon)
• Schisandra
• Is-bogsiin (prunella)
• Skullcap (Baicalin iyo Wogonin)
• Idaha Sorrel
• Sida Wu Tang
• Sideritis
• Spikenard (Aralia)
• Spirulina
• St. John Wort
• Sulforaphane
• Sutherlandia
• Tao Hong Si Wu
• Taurine
• Thunder God Vine (Triptolide)
• Tocopherols (sida Vitamin E ama Linalool)
• Tribulus R
• Tu Si Zi
• TUDCA
• Vitamin A (inkasta oo retinoids kale ay joojiyaan NRF2)
• Faytamiin C (qiyaas sare oo keliya, qiyaas yar ayaa xannibaya NRF2)
• Vitex/ Geed daahir ah
• Peony cad (Paeoniflorin ka Paeonia lactiflora)
• Dacar (Hispidulin iyo Artemisinin)
• Xiao Yao Wan (Wanderer bilaash ah oo fudud)
• Yerba Santa (Eriodictyol)
• Yuan Zhi (Tenuigenin)
• Zi Cao (wuxuu yarayn doonaa NRF2 kansarka)
• Zinc
• Ziziphus Jujube

Hormoonnada iyo Neurotransmitters:

• Adiponectin
• Adropin
• Estrogen (laakiin waxaa laga yaabaa inay hoos u dhigto NRF2 ee unugyada naaska)
• Melatonin
• Progesterone
• Quinolinic acid (jawaab ka hortag ah si looga hortago excitotoxicity)
• Serotonin
• Hormoonnada tayroodhka sida T3 (waxay kordhin karaan NRF2 unugyada caafimaadka qaba, laakiin waxay ku yareeyaan kansarka)
• Vitamin D

Daawooyinka/Daawaynta iyo Kiimikada:

• Acetaminophen
• acetazolamide
• Amlodipine
• Aurafin
• Bardoxolone methyl (BARD)
• Benznidazole
• BHA
• CDDO-imidazolide
• Ceftriaxone (iyo beta-lactam antibiyootiga)
• Cialis
• Dexamethasone
• Diprivan (Propofol)
• Eriodictyol
• Exendin-4
• Ezetimibe
• Fluoride
• Fumarate
• HNE (oxidized)
• Idazoxan
• Arsenic-ka aan organic ahayn iyo arsenite sodium
• JQ1 (waxaa laga yaabaa inay joojiso NRF2 sidoo kale, aan la garanayn)
• Letairis
• Melphalan
• Methazolamide
• Methylene Blue
• Nifedipine
• NSAIDs
• Oltipraz
• PPIs (sida Omeprazole iyo Lansoprazole)
• Protandim - natiijooyin fiican oo ku jira vivo, laakiin daciif ah / aan ka jirin firfircoonida NRF2 ee bini'aadamka
• Probucol
• Rapamycin
• Reserpine
• ruthenium
• Sitaxentan
• Statins (sida Lipitor iyo Simvastatin)
• tamoxin
• Tang Luo Ning
• tBHQ
• Tecfidera (Dimethyl fumarate)
• THC (ma u xoog badan sida CBD)
• Theophylline
• Umbelliferone
• Ursodeoxycholic acid (UDCA)
• Verapamil
• Viagra
• 4-Acetoxyphenol

Dariiqooyinka/ Qodobbada Qoraalka:

• ?7 nAChR firfircoonida
• AMPK
• bilirubin
• CDK20
• CKIP-1
• CYP2E1
• EAATs
• Gankyrin
• Gremlin
• GJA1
• H-ferritin ferrooxidase
• HDAC inhibitors (sida valproic acid iyo TSA, laakiin waxay sababi karaan xasiloonida NRF2)
• Heat Shock Proteins
• IL-17
• IL-22
• Klotho
• let-7 (wuxuu garaacayaa mBach1 RNA)
• MAPK
• aqbalayaasha Michael (inta badan)
• miR-141
• miR-153
• miR-155 (sidoo kale waxay garaacdaa mBach1 RNA)
• miR-7 (maskaxda, waxay ka caawisaa kansarka iyo schizophrenia)
• Darajada1
• Cadaadiska Oxidatives (sida ROS, RNS, H2O2) iyo Electrophiles
• PGC-1?
• PKC-delta
• PPAR-gamma (saamaynta isku-dhafka ah)
• Sigma-1 ka-hortagga soo-dhoweynta
• SIRT1 (waxay ku kordhisaa NRF2 maskaxda iyo sambabada laakiin waxaa laga yaabaa inay hoos u dhigto guud ahaan)
• SIRT2
• SIRT6 (Beerka iyo Maskaxda)
• SRXN1
• Ka-hortagga TrxR1 (dhinac ama hoos u dhac sidoo kale)
• Zinc protoporphyrin
• 4-HHE

Wax kale:

• Ankaflavin
• asbestos
• Avicins
• Bacillus amyloliquefaciens (loo isticmaalo beeraha)
• Carbon Monoxide
• Daphnetin
• Depletion Glutathione (Dhamaystii 80% ~ 90% suurtogal ah)
• Jimicsiga koraiensis
• hepatitis C
• Herpes (HSV)
• Geed dambaska Hindiya
• Xididka Indigowoad
• Isosalipurposide
• Isorhamentin
• Monascin
• Omaveloxolone (xoog leh, aka RTA-408)
• PDTC
• Selenium Deficiency (la'aanta selenium waxay kordhin kartaa NRF2)
• Larch Siberian
• Sophoraflavanone G
• Tadehagi triquetrum
• Toona sinensis (7-DGD)
• Ubax buunka
• 63171 iyo 63179 (xoog leh)

Dariiqa calaamadaynta nukliyeerka 2-xiriirka 2, oo sida ugu wanaagsan loo yaqaan gaabin Nrf2, waa arrin qoraal ah oo ka ciyaarta doorka ugu weyn ee nidaaminta hababka difaaca jirka ee antioxidant-ka ee jirka bini'aadamka, gaar ahaan si loo xakameeyo cadaadiska oksaydhka. Iyadoo heerarka korodhka cadaadiska oksaydhisku ay dhaqaajin karaan Nrf2, saameynteeda si weyn ayaa loo wanaajiyey iyada oo loo marayo joogitaanka xeryahooda gaarka ah. Cuntooyinka qaarkood iyo kaabisyada qaarkood waxay caawiyaan firfircoonida Nrf2 ee jidhka bini'aadamka, oo ay ku jiraan isothiocyanate sulforaphane ka soo baxa broccoli. Dr. Alex Jimenez DC, CCST Insight

Sulforaphane iyo Saameyntiisa Kansarka, Dhimashada, Gabowga, Maskaxda iyo Dhaqanka, Cudurrada Wadnaha & in ka badan

Isothiocyanates waa qaar ka mid ah xeryahooda dhirta ee ugu muhiimsan ee aad ka heli karto cuntadaada. Fiidiyowgaan waxaan u sameynayaa kiiskii ugu badnaa ee abid la sameeyo. Fiiro gaar ah oo gaaban? U gudub mawduuca aad jeceshahay adiga oo gujinaya mid ka mid ah dhibcaha wakhtiga hoose. Jadwalka wakhtiga oo buuxa hoos

Qaybaha muhiimka ah:

• 00:01:14 - Kansarka iyo dhimashada
• 00:19:04 - gabowga
• 00:26:30 - Maskaxda iyo dhaqanka
• 00:38:06 - Dib u soo koobid kama dambays ah
• 00:40:27 - Qiyaasta

Waqtiga buuxa:

• 00:00:34 - Horudhaca sulforaphane, diiradda weyn ee fiidiyowga.
• 00:01:14 - Cunista khudaarta caleenta leh iyo hoos u dhigista dhammaan dhimashada.
• 00:02:12 - Khatarta kansarka qanjirka 'prostate'.
• 00:02:23 - Khatarta kansarka kaadiheysta.
• 00:02:34 - Kansarka sambabada ee sigaarka cabba.
• 00:02:48 - Khatarta kansarka naasaha.
• 00:03:13 - mala awaal: ka waran haddii aad hore u qabtid kansar? (dhexdhexaad ah)
• 00: 03: 35 - Habka macquulka ah ee wadista kansarka iyo xogta xiriirka dhimashada.
• 00:04:38 - Sulforaphane iyo kansarka.
• 00: 05: 32 - Caddaynta xayawaanka oo muujinaysa saamaynta xooggan ee brokoli ka soo baxa burooyinka ee horumarinta burooyinka kaadiheysta ee jiirka.
• 00:06:06 - Saamaynta kabista tooska ah ee sulforaphane ee bukaanka kansarka qanjirka 'prostate'.
• 00: 07: 09 - Bioaccumulation of metabolites isothiocyanate ee nudaha naaska dhabta ah.
• 00:08:32 - Joojinta unugyada asliga ah ee kansarka naasaha.
• 00:08:53 - Casharka taariikhda: brassicas waxaa loo aasaasay inay leeyihiin sifooyin caafimaad xitaa Rome hore.
• 00:09:16 - Awoodda Sulforaphane si kor loogu qaado soosaarka kansarka (benzene, acrolein).
• 00: 09: 51 - NRF2 sida beddelka hiddaha iyada oo loo marayo walxaha jawaabta antioxidant.
• 00: 10: 10 - Sida firfircoonida NRF2 ay kor ugu qaaddo qashinka kansarka iyada oo loo marayo glutathione-S-conjugates.
• 00: 10: 34 - sprouts Brussels waxay kordhiyaan glutathione-S-transferase waxayna yareeyaan dhaawaca DNA.
• 00:11:20 - Cabitaanka sprout broccoli wuxuu kordhiyaa soosaarka benzene 61%.
• 00: 13: 31 - Broccoli sprout homogenate waxay kordhisaa enzymes antioxidant ee marinka hawada sare.
• 00: 15: 45 - Cunista khudaarta cruciferous iyo dhimashada cudurrada wadnaha.
• 00: 16: 55 - Budada sprout broccoli waxay hagaajinaysaa dufanka dhiigga iyo guud ahaan khatarta cudurrada wadnaha ee nooca 2 ee sonkorowga.
• 00:19:04 - Bilawga qaybta gabowga.
• 00: 19: 21 - Sulforaphane-cuntooyinka qani ku ah waxay kor u qaadaan cimriga kuwa lamid ah 15 ilaa 30% (xaalad gaar ah).
• 00: 20: 34 - Muhiimadda caabuqa hooseeya ee muddada dheer.
• 00: 22: 05 - Khudaarta cruciferous iyo budada broccoli waxay u muuqdaan inay yareeyaan calaamado kala duwan oo barar ah oo bini'aadamka ah.
• 00:23:40 - Dib u habeynta fiidiyowga dhexe: kansarka, qaybaha gabowga
• 00:24:14 - Daraasadaha jiirka ayaa soo jeedinaya in sulforaphane laga yaabo inay wanaajiso shaqada difaaca la qabsiga ee da'da.
• 00:25:18 - Sulforaphane waxay hagaajisay koritaanka timaha ee qaabka jiirka ee bidaarta. Sawirka 00:26:10.
• 00:26:30 - Bilawga maskaxda iyo qaybta habdhaqanka.
• 00:27:18 - Saamaynta brokoli ee ka soo baxa cudurka autism.
• 00:27:48 - Saamaynta glucoraphanin ee shisoofrani.
• 00: 28: 17 - Bilawga wadahadalka niyad-jabka (farsamo macquul ah iyo daraasado).
• 00: 31: 21 - Daraasada jiirka iyadoo la adeegsanayo 10 nooc oo kala duwan oo niyad-jabka ah ayaa muujinaya sulforaphane si la mid ah waxtarka sida fluoxetine (prozac).
• 00: 32: 00 - Daraasadu waxay muujineysaa in si toos ah loo nuugo glucoraphanin ee jiirarka ay si la mid ah waxtar ugu leedahay ka hortagga niyad-jabka ee ka timaadda qaabka cadaadiska bulshada.
• 00: 33: 01 - Bilawga qaybta neurodegeneration.
• 00:33:30 - Sulforaphane iyo cudurka Alzheimers.
• 00:33:44 - Sulforaphane iyo cudurka Parkinson.
• 00:33:51 - Sulforaphane iyo cudurka Hungtington.
• 00: 34: 13 - Sulforaphane waxay kordhisaa borotiinnada shoogga kulaylka.
• 00:34:43 - Bilawga qaybta dhaawaca maskaxda ee dhaawaca ah.
• 00: 35: 01 - Sulforaphane ayaa la isku duraa isla markiiba ka dib markii TBI ay wanaajiso xusuusta (daraasadda jiirka).
• 00: 35: 55 - Sulforaphane iyo caagagga neuronal.
• 00:36:32 - Sulforaphane waxay wanaajisaa barashada qaabka nooca II ee sonkorowga ee jiirarka.
• 00:37:19 - Sulforaphane iyo duchenne dystrophy muruqa.
• 00: 37: 44 - Joojinta Myostatin ee unugyada satalaytka muruqa (in vitro).
• 00: 38: 06 - Dib u soo celinta fiidiyowga dambe: dhimashada iyo kansarka, dhaawaca DNA, cadaadiska oksaydhka iyo bararka, dheecaanka benzene, cudurada wadnaha, nooca II ee sonkorowga, saameynta maskaxda (niyad-jabka, autism, schizophrenia, neurodegeneration), waddada NRF2.
• 00:40:27 - Fikradaha lagu ogaanayo qiyaasta brokoli sprouts ama sulforaphane.
• 00:41:01 - Sheekooyinka ku saabsan biqilka guriga.
• 00:43:14 - On heerkulka karinta iyo hawlaha sulforaphane.
• 00:43:45 - Beddelka bakteeriyada Gut ee sulforaphane ee glucoraphanin.
• 00: 44: 24 - Kaabisyadu waxay si fiican u shaqeeyaan marka lagu daro myrosinase firfircoon ee khudaarta.
• 00:44:56 - Farsamooyinka karinta iyo khudaarta cruciferous.
• 00:46:06 - Isothiocyanates sida goitrogens.

Marka loo eego daraasado badan oo cilmi baaris ah oo hadda jira, dariiqa calaamadaynta nukliyeerka 2-xiriirka 2, ee loo yaqaan Nrf2, waa arrin aasaasi ah oo qoraal ah kaas oo dhaqaajiya hababka difaaca unugyada unugyada si ay uga saaraan jirka bini'aadamka labadaba arrimaha dibadda iyo gudaha iyo ka hortagga kororka. heerarka cadaadiska oksaydhka. Baaxadda macluumaadkayadu waxay ku kooban tahay xanuunka loo yaqaan 'chiropractic' iyo arrimaha caafimaadka laf dhabarta. Si aad ugala hadasho mawduuca, fadlan xor u noqo inaad waydiiso Dr. Jimenez ama nagala soo xidhiidh at�915-850-0900 .

Waxaa soo saaray Dr. Alex Jimenez

Mawduuc Dheeraad ah: � Xanuun Dhabar Ba'an

Xanuunka dhabarka�waa mid ka mid ah sababaha ugu badan ee naafada iyo maalmaha shaqada ka baaqda ee adduunka oo dhan. Dhabar xanuunka waxa loo aaneynayaa sababta labaad ee ugu badan ee booqashooyinka xafiiska dhakhtarka, oo ay ka badan yihiin kaliya caabuqyada neef-mareenka sare. Qiyaastii 80 boqolkiiba dadku waxay la kulmi doonaan xanuunka dhabarka ugu yaraan hal mar noloshooda oo dhan. Laf-dhabarta waa qaab dhismeed kakan oo ka kooban lafo, kala-goysyo, seedaha, iyo murqaha, iyo unugyo kale oo jilicsan. Dhaawacyada iyo/ama xaaladaha sii xumeeyay, sida�maqaarka herniated, ugu dambeyntii waxay keeni kartaa calaamadaha xanuunka dhabarka. Dhaawacyada isboortiga ama dhaawacyada shilalka baabuurta ayaa inta badan ah sababta ugu badan ee xanuunka dhabarka, si kastaba ha ahaatee, mararka qaarkood dhaqdhaqaaqa ugu fudud ayaa keeni kara natiijooyin xanuun leh. Nasiib wanaag, xulashooyinka daaweynta kale, sida daryeelka xanuunka loo yaqaan 'chiropractic care', ayaa kaa caawin kara yareynta xanuunka dhabarka iyada oo loo marayo isticmaalka isbeddelka laf-dhabarka iyo manfacyada gacanta, ugu dambeyntii hagaajinta xanuunka. �

DHEERAAD AH | Mawduuca MUHIIMKA AH: Lagu taliyay El Paso, TX Chiropractor

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