Daawooyinka Dib-u-soo-noolaynta: Sahaminta Faa'iidooyinka & Khatarta

Maalmahan, shakhsiyaadka isku dayaya inay iska ilaaliyaan qalliinka waxay leeyihiin doorashooyin daweyn oo badan. Daawaynta dib-u-soo-noolaynta ma caawin kartaa daaweynta dhaawacyada neuromusculoskeletal?

Daaweyn Dib-u-dejin ah

Daawooyinka dib-u-cusboonaysiinta ayaa ka faa'iidaysta unugyada cayriin ee jidhka waxaana loo isticmaalaa daaweynta kansarka iyo si loo yareeyo khatarta caabuqyada. (Bulshada Kansarka Maraykanka. 2020) Cilmi baadhayaashu waxay raadinayaan habab kale oo ay ugu isticmaalaan unugyadan daawaynta caafimaadka.

Waa maxay Unugyadani

• Unugyada stem-ku waa unugyo aan si gaar ah loo aqoon oo u kori kara unug kasta xaaladaha qaarkoodna waxay isu cusboonaysiiyaan tiro aan xadidnayn. (Machadyada Caafimaadka Qaranka. 2016)
• Unugyadaan waxaa laga helaa embriyaha iyo unugyada qaangaarka.
• Waxaa jira laba nooc oo unugyo ah - pluripotent and somatic. (Machadyada Caafimaadka Qaranka. 2016)
• Unugyadani waxay bedeli karaan oo noqon karaan mid ka mid ah unugyada jidhka.
• Unugyada somatic-ka ama unugyada asliga ee qaangaarka waxay sameyn karaan unug ama xubin dhan. (Machadyada Caafimaadka Qaranka. 2016)

Therapy

Daaweynta unugyada dib-u-cusboonaysiinta waxay u isticmaashaa unugyadan sidii daawaynta cudur ama xaalad.

• Unugyada dib-u-cusboonaysiinta waxaa la siiyaa shakhsiyaad si ay u beddelaan unugyadii la burburiyey ama dhintay.
• Marka laga hadlayo kansarka, waxaa laga yaabaa in loo isticmaalo in lagu caawiyo jidhku inuu dib u helo awood uu ku soo saaro unugyo dib u soo kabasho ka dib daaweynta. (Bulshada Kansarka Maraykanka. 2020)
• Shakhsiyaadka qaba myeloma badan iyo noocyo gaar ah oo leukemia ah, daaweynta unugyada dib-u-cusboonaysiinta ayaa loo isticmaalaa si loo baabi'iyo unugyada kansarka.
• Daaweynta waxaa loo yaqaan Saamaynta tallaalka-ka-hortagga-buro/GvT, halkaasoo ku-deeqaha unugyada dhiigga cad/WBC-yada loo isticmaalo baabi'inta burada kansarka. (Bulshada Kansarka Maraykanka. 2020)

Maxay Daweyn Karaan

Tani waa daaweyn cusub oo weli ku socota cilmi baaris. Maamulka Cuntada iyo Dawooyinka ayaa kaliya u ansixiyay kansarrada qaarkood iyo xaaladaha saameeya dhiigga iyo habka difaaca jirka. (Xarumaha Xakamaynta iyo Kahortagga Cudurrada. 2019) daawaynta unug dib-u-soo-noolayntu waa FDA-loo oggolaaday in lagu daweeyo: (Machadka Qaranka ee Kansarka. 2015)

• Leukemia
• Lymphoma
• Meelo badan
• Neuroblastoma
• Waxa kale oo loo isticmaalaa in lagu yareeyo khatarta caabuqa ka dib unugyada unugyada dib-u-soo-kabashada ee shakhsiyaadka qaba kansarka dhiigga. (Maamulka Cuntada iyo Dawooyinka ee Maraykanka. 2023)

Cilmi-baadhayaashu waxay baranayaan sida unugyadani u daweyn karaan xaaladaha kale. Tijaabooyin caafimaad ayaa falanqeynaya sida loo isticmaalo daawaynta cudurada neurodegenerative sida:

• Parkinson's
• Alzheimer's
• Cudurka sclerosis badan - MS
• Amyotrophic lateral sclerosis - ALS. (Riham Mohamed Ali. 2020)

Noocyada Unugyada

Inta lagu jiro daawaynta unugyada dib-u-cusboonaysiinta, unugyada waxaa la siiyaa iyada oo loo marayo khadka xididka. Saddexda meelood ee laga heli karo unugyada dhiig-samaynta ayaa ah dhuuxa lafta, xuddunta, iyo dhiigga. Ku-tallaalidda waxaa ka mid noqon kara:Bulshada Kansarka Maraykanka. 2020)

Autologous

• Unugyada waxa laga soo qaadaa qofka daawaynta la siin doono.

Allogeneic

• Unugyada waxaa ku deeqay shaqsi kale.

Syngeneic

• Unugyadu waxay ka yimaadaan mataano isku mid ah, haddii ay jiraan.

Ammaanka

Daawaynta ayaa muujisay inay bixiso faa'iidooyin laakiin waxaa jira khataro.

• Hal khatar ayaa loo yaqaan cudur-iska-caabbinta-ka-hortagga-cudurka - GVHD.
• Waxay ku dhacdaa saddex-meelood meel ilaa kala badh qaatayaasha allogeneic.
• Tani waa meesha uu jidhku aqoonsan waayo unugyada dhiiga cad ee ku-deeqaha oo uu weeraro iyaga oo keenaya dhibaatooyin iyo calaamado jidhka oo dhan ah.
• Si loo daaweeyo daawooyinka GVHD waxaa la siiyaa si loo xakameeyo habka difaaca si loo joojiyo weerarka unugyada ku-deeqaha. (Bulshada Kansarka Maraykanka. 2020)

Khataraha kale ee suurtagalka ah waxaa ka mid noqon kara:Bulshada Kansarka Maraykanka. 2020)

• Dib u soo noqoshada kansarka
• Kansar cusub
• Cudurka cagaarshowga veno-occlusive
• Ka-tallaalidda ka-dib-u-tallaalidda lymphoproliferative disorder - PTLD

Fursadaha mustaqbalka

Mustaqbalka daawaynta unuggu waa mid rajo leh. Cilmi-baaris ayaa socota si loo ogaado sida unugyadan ay u daweyn karaan xaaladaha oo ay u helaan habab cusub oo lagu daweeyo oo lagu daweeyo cudurrada.
Daawooyinka dib-u-cusboonaysiinta ayaa la baadhay in ka badan labaatan sano xaaladaha sida macular degeneration, glaucoma, stroke, iyo cudurka Alzheimers. (Machadyada Caafimaadka Qaranka. 2022daawayntani waa daaweyn cusub oo loo isticmaali karo daawaynta mustaqbalka oo qayb ka ah a hab dhaqan badan dhaawacyada neuromusculoskeletal iyo xaaladaha.

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Habka Bilaabidda Bukaanka Degdegga ah

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tixraacyada

Bulshada Kansarka Maraykanka. (2020). Sida unugyada asliga ah iyo ku-tallaalidda dhuuxa lafta loo isticmaalo daaweynta kansarka.

Machadyada Caafimaadka Qaranka. (2016). Aasaaska unugyada stem.

Xarumaha Xakamaynta iyo Kahortagga Cudurrada. (2019). Unugyada stem iyo alaabta exosome.

Machadka Qaranka ee Kansarka. (2015). Ku-tallaalidda unugyada stem ee daaweynta kansarka.

Maamulka Cuntada iyo Dawooyinka ee Maraykanka. (2023). FDA waxay ansixisay daaweynta unugyada bukaanka qaba kansarka dhiigga si loo yareeyo khatarta caabuqa ka dib tallaalka unugyada asliga ah.

Aly RM (2020). Xaaladda hadda ee daaweynta unugyada stem-ku-saleysan: dulmar. Baaritaanka unugyada stem, 7, 8. doi.org/10.21037/sci-2020-001

Bulshada Kansarka Maraykanka. (2020). Waxyeellooyinka beerista unugga stem ama dhuuxa lafta.

Machadyada Caafimaadka Qaranka. (2022). Dhigista daawaynta unugyada asliga ku salaysan macnaha guud.