Bayooloji ee Spondylitis Ankylosing: El Paso Clinic Back

Ankylosing spondylitis waa xaalad barar ah oo keenta xanuun iyo qallafsanaan ku dhaca xubnaha laf dhabarta.. Waqti ka dib, waxay u gudbi kartaa isku darka lafaha laf dhabarta / laf dhabarta, xaddidaysa dhaqdhaqaaqa laf dhabarta waxayna u horseedi kartaa calaamado aan raaxo lahayn. Xaaladdu aad ayay ugu badan tahay ragga laakiin sidoo kale waxay saamaysaa dumarka. Ma jirto sabab la garanayo, oo keli ah, laakiin shakhsiyaad gaar leh hidde-side, HLA-B27, waxay leeyihiin khatar sii kordheysa oo ah inay ku dhacaan xaaladda. Si kastaba ha ahaatee, hidda-wadaha laftiisa macnaheedu maaha in qofku leeyahay spondylitis ankylosing; genetics iyo arrimo kale oo ka baxsan iyo deegaanka ayaa iyaguna door ka ciyaara. DMARDs, or Cudur-wax-ka-beddelaya Dawooyinka Ka-hortagga Rheumatka, joojiso bararka. Daawaynta DMARD ee soo ifbaxday waxay isticmaashaa bayooloji kuwaas oo sii beegsanaya oo xakameynaya xeryahooda bararka gaarka ah.

Bayoolaji

Si ka duwan daawooyinka caadiga ah, kuwaas oo la farsameeyey, cilmiga noolaha waxa laga sameeyaa iyo gudaha ilo noolaha.

• Waxay ku koraan dhaqamo ama laga goosto dhiigga.
• Bayolojigu waa adag yihiin waana qaali.
• Cilmiga bayoolajiga ayaa bixiya qaar ka mid ah daawaynta ugu awoodda badan xaalado badan.
• Laba bayooloji oo caadi ahaan loo isticmaalo daawaynta ankylosing spondylitis waa:
• Xakamaynta TNF.
• IL-17 inhibitors.

Kahortaggayaasha TNF

• TNF - factor necrosis burada, Xakamaynta TNF waa dawo bayooloji ah oo bartilmaameedsan oo xakameysa TNF, taas oo ku lug leh hababka bararka ee jirka oo dhan.
• Joojinta ama xakamaynta TNF waxay yaraynaysaa bararka waxayna dib u dhigi kartaa horumarka spondylitis ankylosing.
• Waxaa la isku duri karaa irbad ama faleebo si daawada loo siiyo.

Waxyaabaha kale ee saameynaya

Dhibaatooyinka soo raaca ee la xiriira dawadan, iyo xaalado kale, waxaa ka mid ah:

• Dareenka maqaarka - finan ama caabuq
• Qalabka wadnaha
• lupus
• Lymphoma
• Xanuunada bartilmaameedsada habka neerfaha waxaa loo yaqaanaa xanuunada demiyelinating. Kuwaas waxaa ka mid noqon kara xaalado ay ka mid yihiin:
• Cagaarshow Multiple
• Cudurka 'Guillain-Barré Syndrome'

Xakamaynta IL-17

• IL - interleukin - IL-17 waa borotiin ku lug leh hababka bararka iyo xaaladaha.
• IL-17 inhibitors waxay xakameysaa caabuqa kuwaas oo ah dawooyin cusub oo la muujiyay inay ka faa'iideysanayaan kuwa qaba ankylosing spondylitis.
• Dhakhaatiirtu waxay inta badan maamulaan IL-17 inhibitors iyada oo loo marayo duritaanka.

Waxyaabaha kale ee saameynaya

Waxyeelooyinka yaryar waxaa ka mid ah:

• Madax
• Sanka oo dareeraya
• Xanaaq goobta laga muday.

Waxyeellooyinka ka sii daran waxaa ka mid ah:

• Kansarrada qaarkood
• Caabuqyo daran
• Cadaadis dhiig oo sarreeya

Daaweyn kale

Yoolalka daawaynta loogu talagalay ankylosing spondylitis waxaa ka mid ah:

• Hoos u dhigida horumarka xanuunka.
• Xanuunka oo yaraada.
• Yaraynta xanuunka.
• Hagaajinta ama ilaalinta kala-goysyada iyo dhaqdhaqaaqa laf-dhabarta.

Bayolojigu maaha daawaynta safka koowaad ee spondylitis ankylosing.

• Bixiyeyaasha badanaa waxay marka hore ku daaweeyaan ogaanshaha bilowga ah daawooyinka ka hortagga caabuqa, sida NSAIDs, si loo yareeyo bararka oo loo yareeyo horumarka xaaladda.
• Daryeelka lafdhabarta iyo daaweynta jireed ayaa lagula talinayaa si loo ilaaliyo iyo/ama loo hagaajiyo booska, xoogga muruqa, iyo dulqaadka.
• Hab-nololeedka lagu taliyay iyo wax ka beddelka nafaqada.
• Tabobarka joogsiga oo fidsan iyo jimicsiyo.
• Xeeladaha dhaqdhaqaaqa ugu fiican si si badbaado leh oo kalsooni leh loogu dhamaystiro hawlaha maalinlaha ah.

Daawooyinka Nafleyda

Cilmiga bayoolojiga loogu talagalay spondylitis ankylosing ayaa laga yaabaa ama laga yaabaa inay ku habboonaato. Daawooyinkaan waxaa loogu tala galay in lagu nafiso caabuqa laxiriira xaalada ayna hoos u dhigaan horumarka xanuunka. Kooxdaada daryeelka caafimaadka ayaa kula shaqayn doona si ay u go'aamiyaan ikhtiyaarka/daawaynta saxda ah oo ay kuu sharxaan faa'iidooyinka, halista, iyo noocyada daawaynta. Waxay la socon doonaan xaaladda, la socon doona horumarka, oo ay u hagaajin doonaan qorshaha si habboon.

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Qiimaynta Hormone Therapy

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tixraacyada

Ankylosing spondylitis. (nd) Machadka Qaranka ee Arthritis-ka iyo Musculoskeletal iyo Cudurada Maqaarka. Waaxda Caafimaadka iyo Adeegyada Aadanaha ee Mareykanka. Waxaa laga heli karaa: www.niams.nih.gov/health-topics/ankylosing-spondylitis#:~:text=Ankylosing%20spondylitis%20is%20a%20type,the%20spine%20can%20cause%20stiffness (la helay: Oktoobar 12, 2022).

Chen C, Zhang X, Xiao L, Zhang X, Ma X. Waxtarka Isbarbardhigga Nidaamyada Daaweynta Nafleyda ee Ankylosing Spondylitis: Dib-u-eegis Nidaamsan iyo Falanqaynta Meta-Shabakadda. Daawo (Baltimore). 2016 Mar;95(11):e3060. doi: 10.1097/MD.0000000000003060. PMID: 26986130; PMCID: PMC4839911.

Gerriets V, Goyal A, Khaddour K. Tumor Necrosis Factor Factor. [La cusbooneysiiyay 2022 Luulyo 4]. Gudaha: StatPearls [Internet]. Treasure Island (FL): Daabacaada StatPearls; 2022 Jan-. Waxaa laga heli karaa: www.ncbi.nlm.nih.gov/books/NBK482425/

Lindström, U., Olofsson, T., Wedrén, S. iyo al. Daaweynta bayoolojiga ee ankylosing spondylitis: daraasad heer qaran ah oo ku saabsan dariiqooyinka daawaynta ee heerka bukaan-socodka ee waxqabadka kiliinikada. Arthritis Res Ther 21, 128 (2019). doi.org/10.1186/s13075-019-1908-9

Yin, Y., Wang, M., Liu, M. iyo al. Waxtarka iyo badbaadada IL-17 inhibitors ee daaweynta ankylosing spondylitis: dib u eegis nidaamsan iyo falanqaynta-meta. Arthritis Res Ther 22, 111 (2020). doi.org/10.1186/s13075-020-02208-w