Endocrinology functional: menopause iyo lafo-jileecu

Ma dareemaysaa:

• Perimenopause?
• Caabuqa kala goysyada?
• Beddelka dhererka wareegga caadada?
• Biriishyo kulul?
• Isku dheelitir la'aanta hormoonnada?

Haddii aad la kulanto mid ka mid ah xaaladahan, markaas waxaa laga yaabaa inaad la kulanto menopause iyo calaamadihiisa.

Markay haweeneydu garaacdo afartanaad dabadood oo ay gasho horraanta kontonaadyada, waxay maraan habka gabowga ee dabiiciga ah ee loo yaqaan menopause. Menopause waa marka haweeneydu aysan caadada dhicin qiyaastii laba iyo toban bilood oo isku xigta sidoo kalena aysan uur yeelan karin. Menopause-ka waxaa ku yimaadda calaamado aan fiicneyn sida hurdo kulul, qallayl siilka, iyo dheellitirka hormoonnada. Dumarka, dheelli-tirnaan la'aanta hoormoonku waxay u dhaxayn kartaa inay yeeshaan hormoonno aad u badan ama aad u yar oo ku jira dhiigga jidhka. Marka menopause uu dhaco, luminta shaqada ugxan-sidaha ee jirka haweeneyda waxay saameyn ku yeelan kartaa caafimaadkooda lafaha, taasoo keenta lafo-beelka xubnaha.

Osteoporosis iyo menopause

Si kastaba ha ahaatee, waxaa la yaab leh in hormoonka estrogen uu awoodo door ka ciyaar horumarinta osteoarthritis-ka iyo marka haweeneydu ku hoos jirto marxaladda menopausal. Waxay la kulmi karaan hoos u dhac ku yimaada heerarka estrogen, iyo lafo-jileecu waxay bilaabi doontaa inay burburiso lafaha iyo kala-goysyada, taasoo keenta caabuq dabadheeraad ah. Daraasado ayaa helay Marka hormoonnada estrogen ay bilaabaan inay isbeddelaan inta lagu jiro isbeddellada menopausal ee caafimaadka qaba, waxay bilaabi doonaan inay isbeddelaan ka dibna si lama filaan ah u dhacaan. Waxay sheegeen in estrogen uu ka caawiyo ka hortagga lafaha inay daciifaan burburka dabiiciga ah. Jabka kasta oo ka yimaada shilalka wuxuu keeni karaa xanuun, dhaqdhaqaaqa oo yaraada, iyo shaqada caadiga ah ee jirka dumarka sababtoo ah lafo-jileecu.

Waxaa jira xitaa caddayn dheeraad ah in isbedbedelka estradiol ee laga yaabo inuu xitaa si aad ah ugu caddeeyo perimenopause oo laga yaabo inuu awoodi waayo inuu si fiican ula xiriiro cufnaanta lafaha iyo luminta jidhka. Sidaa darteed, inta lagu jiro marxaladda menopausal, cufnaanta lafaha ayaa sii xumaan doona marka dumarku yeeshaan lafo-jileec. Waxaa jiray warar xan ah oo sheegaya in lafo-jileecu ay tahay wax uusan qofku ka walwalin sababtoo ah waxay dhacdaa oo keliya haddii ay jirto taariikh qoys oo ah lafo-jileec. Nasiib darrose, lafo-jileecu waa cudur lafo caadi ah, iyo haysashada taariikhda qoyska ee cudurka waxay kordhin kartaa fursadaha. Si kastaba ha ahaatee, waxaa sidoo kale jira arrimo kale oo halis ah oo keeni kara lafo-jileecu sida:

• Aalkolo xad dhaaf ah
• Aamiin
• Sigaarka
• Miisaanka jidhka oo hooseeya

Cilmi baaris ayaa muujinaya in lafo-jileecu uu bilaabo marka ay haweeneydu ku jirto bilowga marxaladda menopausal oo ay joojiso ugxan-sidaha, wareegga caadada ee bilaha ah ayaa istaagaya. Heerkeeda estrogen ayaa si weyn u joogsan doona, sidoo kale. Waxay sheegtay in haweenku ay yeelan karaan lafo-beelid guud tobanka sano ee ugu horreeya ee ka dambeeya menopause. Marka ay jirto la'aanta estrogen ee jirka sababtoo ah menopause, luminta cufnaanta lafaha ayaa aad uga muhiimsan waxayna sababi kartaa jabka jirka. Daraasado ayaa helay marka laga reebo in xirfadlayaasha daryeelka caafimaadka ee maxaliga ahi ay waydiin doonaan haweenka qadarka cufnaanta lafaha ee lumay intii lagu jiray kala-guurka menopausal iyo marka ay bilaabaan. Waxay xitaa ogaadeen in hoormoonka follicle-kicinta ee haweenka uu isbeddelay sidoo kale intii lagu jiray kala-guurka menopausal.

Dib-u-habaynta lafaha

Intaas waxaa sii dheer, daraasado la helay in ka badan 20 qof oo Maraykan ah ayaa saameeya lafo-jileecu, taasina waxay u horseedi kartaa ilaa 1.5 milyan oo lafo jaban sannadkii, taas oo ka dhigaysa lafo-jileecu inay noqoto mid ka mid ah dhibaatooyinka caafimaadka bulshada ee ugu horreeya. Daraasado badan ayaa xitaa lagu ogaaday in haweenku ay lumin doonaan ugu yaraan boqolkiiba konton lafaha trabecular-ka, iyo qiyaastii boqolkiiba soddon ee lafaha kortikal ee jirkooda ayaa ugu dambeyntii lumin doona tobanka sano ee ugu horreeya inta lagu jiro marxaladda menopause. Dumarku waa inay ugu yaraan qaataan fitamiin D-ga dheeriga ah si ay u hubiyaan in lafahoodu caafimaad qabaan oo aanay u nuglayn lafo beel ama jab.

Waxaa jira macluumaadka ku saabsan Waa maxay sababta lafaha lumay ay u muuqdaan inay soo dedejiyaan ka dib marka caadada haweeneydu dhammaato iyo sababta dib-u-qaabaynta lafaha ay gacan ka geysan karto beddelka lafaha hore ee ku lumay lafo-beelka ama jabka awgeed. Waxa la yaab leh in dib-u-habaynta lafuhu ay tahay hab lagu beddelo lafo hore oo lafo cusub oo jidhka ah, waxaanay ka kooban tahay shan waji. Waxay kala yihiin:

• FuritaankaInta lagu jiro marxaladan dib-u-qaabaynta lafaha, osteoclasts ayaa la qorayaa oogada lafta.
• Dib u dejintaMarxaladdan, osteoclast-ka waxa loo abuuraa microenvironment aashito ah oo ku yaal dusha sare ee lafta, sidaas awgeedna milanto oo dib u soo celinayso nuxurka macdanta lafaha.
• Dib-u-noqoshadaMarxaladdan, osteoclast waxa uu maraa apoptosis ka dibna waxa lagu qorayaa oogada lafta.
• Formation: Tani waa wejiga ugu dambeeya ee dib-u-habaynta lafaha sida osteoclast-ku wuxuu kaydiyaa kolajka ka dibna la macdaneeyay si ay u sameeyaan laf cusub oo jirka ah.

Ugu Dambeyn

Menopause waa qayb dabiici ah oo ka mid ah heerarka hoormoonka oo hoos u dhacaya, dumarkuna ma qaadi karaan uur dambe. Mid ka mid ah calaamadaha ugu badan ee dumarka menopausal ay la kulmaan waa lafo-jileecu. Lafo-jileecu waa marka lafaha noqdaan kuwo jajaban oo ay ka jabaan dhicitaan ama dhaawac. Dumarku waxay u baahan yihiin inay qaataan dawooyinka caafimaadka lafaha si ay lafaha iyo jidhkuba si sax ah ugu shaqeeyaan. Qaar wax soo saarka waxaa loogu talagalay in lagu taageero dheef-shiid kiimikaadka estrogen ee jirka dumarka iyo ragga iyo sidoo kale wax soo saarka si loo taageero dheellitirka hormoonnada iyo caadada caadiga ah ee haweenka da'da taranka.

Baaxadda macluumaadkayagu waxay ku xaddidan tahay xanuunka loo yaqaan 'chiropractic, musculoskeletal', iyo arrimaha caafimaadka neerfaha ama maqaallada daawada shaqeynta, mowduucyada, iyo doodaha. Waxaan isticmaalnaa borotokool caafimaad oo shaqeynaya si aan u daaweyno dhaawacyada ama cilladaha habka muruqyada. Xafiiskayagu waxa uu sameeyay isku day macquul ah oo uu ku bixinayo tixraacyo taageero ah waxana uu aqoonsaday daraasadda cilmi-baadhiseed ee la xidhiidha ama daraasadaha taageeraya qoraaladayada. Waxaan sidoo kale ka dhignaa nuqullo ka mid ah daraasadaha cilmi-baarista ee taageeraya oo ay heli karaan guddiga iyo dadweynaha haddii la codsado. Si aad uga hadasho mawduuca kor ku xusan, fadlan xor u noqo inaad weydiiso Dr. Alex Jimenez ama nala soo xiriir 915-850-0900.

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Tixraacyo:

Duggal, Neel. Waa maxay xidhiidhka ka dhexeeya menopause iyo Arthritis? Caafimaadka, 11 Meey, 2017, www.healthline.com/health/menopause/menopausal-arthritis.

Finkelstein, Joel S, iyo al. Isbeddellada Cufnaanta Macdanta Lafaha inta lagu jiro Kala-guurka Menopause ee Kooxda Haweenka ee Qowmiyadaha badan. The Journal of Clinical Endocrinology iyo Metabolism, Ururka Endocrine Society, Mar. 2008, www.ncbi.nlm.nih.gov/pmc/articles/PMC2266953/.

Rodriguez, Diana, iyo al. �Xiriirka Lafo-jileecu-Menopause.� EverydayHealth.com, 16 Feb. 2016, www.everydayhealth.com/menopause/osteoporosis-and-menopause.aspx.

Rosen, Clifford, iyo Ramon Martinez. �Menopause ka dib iyo lafo-jileeca Shabakadda Caafimaadka Hormoonka, Maarso 2019, www.hormone.org/diseases-and-conditions/menopause/post-menopause-and-osteoporosis.

Sowers, MaryFran R, iyo al. �Qaddarka luminta lafaha ee la xidhiidha wakhtiga ku xeeran Muddada ugu dambaysa ee caadada iyo heerka hormoonka kicinta ee follicle-ka ee ku-meel-gaadhka-guurka.� The Journal of Clinical Endocrinology iyo Metabolism, Ururka Endocrine Society, May 2010, www.ncbi.nlm.nih.gov/pmc/articles/PMC2869543/.

Kooxda, Penn Medicine. Menopause iyo Osteoporosis: waa maxay xidhiidhka ka dhexeeya? � Penn Medicine � Penn Medicine, 18 Mar. 2016, www.pennmedicine.org/updates/blogs/womens-health/2016/march/menopause-iyo-osteoporosis.

Tella, Sri Harsha, iyo J Christopher Gallagher. �Kahortagga iyo daawaynta lafo-jileecu ka dib.� Joornaalka Biochemistry-ka Steroid iyo Biology-ga Molecular, Maktabadda Daawada Qaranka ee Maraykanka, Luulyo 2014, www.ncbi.nlm.nih.gov/pmc/articles/PMC4187361/.

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Ladnaanta Is-dhexgalka Casriga ah- Esse Quam Videri

Jaamacaddu waxay bixisaa xirfado caafimaad oo kala duwan oo kala duwan oo loogu talagalay daawaynta shaqaynaysa iyo isku-dhafka. Hadafkayagu waa inay ku wargeliyaan shakhsiyaadka raba inay isbeddel ku sameeyaan goobaha caafimaadka ee shaqaynaya xog aqoon leh oo ay bixin karaan.