Isticmaalka Bayoolojiga Dabiiciga ah ee Soo Kabashada Dhaawaca Degdega ah

Marka uu jirku sii weynaado awoodda uu nolosha ugu noolaan karo si buuxda ayaa noqon karta mid adag. Isticmaalka bayoolojiga dabiiciga ah ma caawin karaa kor u qaadida awoodda dabiiciga ah ee jidhka si uu u bogsado?

Bayoolajiyada Dabiiciga ah

In kasta oo mararka qaarkood ay tahay ikhtiyaar daawaynta lagama maarmaanka ah, hababka qalliinka ayaa noqon kara khadka ugu horreeya ee daawaynta loo soo bandhigo bukaanka. Bayolojiyada dabiiciga ah waa beddel ka yar weerarrada kaas oo baabi'in kara isbitaal dhigista oo soo dedejisa soo kabashada. (Riham Mohamed Ali, 2020)

Maxay yihiin?

Jidhku wuxuu ku dhashaa qaybo si uu u bilaabo bogsashada iyo soo kabashada. Qaybahan waxaa ka mid ah:

• Unugyada
• Cytokines
• borotiin
• Collagens
• Elastin
• Aaladda Hyaluronic

Waqtiga dhalashada, qaybahani aad bay u badan yihiin laakiin way yaraanayaan marka jirku da'da yahay. Tani waa sababta ay carruurtu uga soo kabtaan dhaawacyada si ka dhaqso badan dadka waaweyn. Soo kabashada dadka waaweyn waxay noqon kartaa mid gaabis ah hoos u dhaca qaybahan dabiiciga ah ee bogsashada. Ujeedada daawaynta bayoolojiga dabiiciga ahi waa in la kordhiyo qaybaha bogsashada iyada oo dib loo soo celinayo qaybihiisa jidhka - autologous - ama keenaya qaybo cusub - allogeneic – ka deeq bixiye. (Machadka Qaranka ee Caafimaadka 2016Doorashada labada ikhtiyaar waxay ku xiran tahay da'da shakhsiga iyo caafimaadka, sababtoo ah kuwa da'da weyn ama caafimaadka jireed ee liita waxay la kulmi karaan dhibaatooyin ka yimaada qadarka hoose ee qaybaha.

• Qaybaha bogsashada ee laga helay ilo deeq-bixiyeyaal ayaa muujin kara ballan-qaad badan, maadaama daawaynta inta badan laga helo unugyo dhalmo oo la tuuray marka dhalmada.
• Unugyada dhalashadu waxay qani ku yihiin qaybaha bogsashada, oo ay ku jiraan ururinta ugu badan ee walxaha bogsiinta dabiiciga ah.
• Waxaa muhiim ah in la ogaado in aysan jirin wax dhib ah oo hooyada ama dhallaanka ka imaanaya alaabta unugyada la helay.

Daawaynta iswada

Ka soo jeeda qofka qaata daawaynta unugga. (Yun Qian, iyo al., 2017)

Platelet-Rich Plasma – PRP

• Balaasmaha qaniga ku ah platelet waxa lagu beeraa iyadoo la sawiro dhiiga qofka oo lagu dhex miiqiyo sentrifuge si loo kala saaro balasmaha.
• Dareeraha ka soo baxay ayaa dib loogu duraa aagga dhaawacan si loo dhaliyo deegaan bogsoon.
• Noocan bayoolojiga dabiiciga ah ayaa waxtar u leh shakhsiyaadka qaba dhaawacyada fudud kuwaas oo si fudud loo hagaajin karo.
• Nidaamkani maaha mid waxtar u leh shakhsiyaadka da'da ah ee hore u lahaa hoos u dhaca qaybaha bogsashada dabiiciga ah.
• Arrimaha hab-nololeedka sida sigaarka, cunto aan caafimaad qabin, iyo ku xadgudubka aalkolada/walaxda ayaa yarayn kara waxtarka daawaynta PRP.

Himilada Dhuuxa Lafta

• Tani waa habsocod xanuun badan oo ku bilaabma in bukaanka la suuxiyo oo lafaha la geliyo si loo soo saaro dhuuxa. (Ururka Kansarka Mareykanka, 2023)
• Sida PRP, guushu waxay ku xidhan tahay da'da qofka, caafimaadka, iyo qaab nololeedkiisa.
• Nidaamyada soo galitaanka ee sidan oo kale ah waxay leeyihiin suurtogalnimada infekshanka sare waxayna u baahan yihiin muddo dheer oo soo kabasho ah.

Unugyada stem-ka-soo-baxa

• Daawaynta unugyada laf-dhabarka ah/baruurta ayaa lagu soo ururiyaa habraac u eg habka liposuction.
• Habka waxaa lagu sameeyaa suuxdin guud waana habsocod soo jiidasho leh.
• Marka nudaha la ururiyo, unugyadu waa la kala saaraa oo dib ayaa loo duraa. (Loubna Mazini, iyo al. 2020)
• Guusha daaweyntu waxay ku xidhan tahay caafimaadka qofka, da'diisa, iyo qaab nololeedkiisa.
• Waxaa jira khatar badan oo ah infekshanka marka la dooranayo habkan iyo muddada soo kabashada ee muddada dheer.

Daaweynta Allogeneic

Unugyada dib-u-soo-nooleynta ee ku saleysan deeq-bixiyeyaasha.

Daaweynta dareeraha Amniotic

Dheecaanka Amniotic wuxuu ka kooban yahay arrimo koritaan oo kala duwan, cytokines, iyo borotiinada anti-bararka kuwaas oo laga yaabo inay kor u qaadaan hagaajinta unugyada, yareeyaan bararka, iyo kicinta dib u soo kabashada gacanta. (Petra Klemmt. 2012)

• La soo ururiyo wakhtiga dhalashada, daawayntani waa daaweyn ku habboon shakhsiyaadka soo gaaray dhaawacyo saameeya hawl-maalmeedka.
• Dhakhaatiirta iyo daaweeyayaasha ayaa isticmaalaya daaweynta dareeraha amniotic si ay u daweeyaan xaalado badan, laga bilaabo lafaha ilaa daryeelka dhaawaca.
• Dareeraha Amniotic waxa la ururiyaa wakhtiga dhalashada waxana uu aad ugu badan yahay qaybaha bogsashada oo kordhay marka loo eego ilaha iswada.
• Dareeraha Amniotic waa difaac-mudnaan (xaddidaad u yeelata ama waxay joojisaa jawaabta difaaca) khatarta diidmadana waa naadir.
• Daawayntan waxaa badanaa lagu sameeyaa xafiiska dhakhtarka iyada oo wakhtiga ugu yar uu hoos u dhaco daaweynta ka dib.

Macnaha magaca koowaad Wharton

• Jelly Wharton waxaa laga soo qaatay xuddunta xilliga dhalmada waxayna ugu horreyn ka kooban tahay walax jel ah oo ka samaysan hyaluronic acid iyo shabakad fiilooyinka kolajka ah.
• Sifooyinkeeda gaarka ah ayaa ka dhigaya mid ku habboon ilaalinta iyo taageeridda xudunta. (Vikram Sabapathy, iyo al., 2014)
• Waxa la rumaysan yahay in ay ku jiraan dad ka mid ah unugyada tarma ee mesenchymal kuwaas oo awood u leh inay u kala soocaan noocyada unugyada kala duwan, iyo arrimo kale oo korriin ah oo qarsoodi ah iyo cytokines. (F. Gao, iyo al., 2016)
• Waxaa loo tixgeliyaa isha ugu qiimaha badan si kor loogu qaado bogsashada unugyo kala duwan, oo ay ku jiraan lafaha, carjawda, maqaarka, iyo unugyada dareemayaasha.
• Waa difaac-mudnaan leh oo leh khatar yar oo diidmo ah oo ay yar tahay haddii ay jirto, wakhtiga soo kabashada ka dib daaweynta gudaha xafiiska.

Exosomes

• Exosomes waa unugyo yaryar, xuub-ku-xidhan oo door ka qaata isgaadhsiinta unugyada gudaha ee jirka. (Carl Randall Harrell, iyo al., 2019)
• Waxay ka kooban yihiin noocyo kala duwan oo unugyo noole ah, oo ay ku jiraan borotiinno, lipids, acids nucleic (sida RNA), iyo molecules calaamadaha.
• Waxay u adeegaan sidii gaadiid loogu wareejinayo molecules calaamadaha hal unug oo u oggolaanaya unugyadu inay saameeyaan habdhaqanka iyo shaqada unugyada deriska ama fog.
• Waxa laga soo ururin karaa ama laga go'doomi karaa dareeraha noole ee kala duwan iyo dhaqamada unugyada iyada oo loo marayo farsamooyin gaar ah laakiin aad ayay u adag yihiin marka la soo ururiyo xilliga dhalashada.
• Exosomes ee ku dhex jira xudunta ayaa loo isticmaalaa dayactirka nudaha iyo dib u soo kabashada, taasoo calaamad u ah unugyada si kor loogu qaado:
• Kordhinta - korodhka tirada unugyada iyada oo loo marayo qaybinta unugyada.
• Kala-duwanaanshaha - beddelka unugyada aan khaaska ahayn ee unugyada gaarka ah.
• Bogsiinta unugyada meelaha dhaawacan ama dhaawacan.
• Exosomes ka soo baxa xudunta ayaa leh difaac-mudnaan leh khatarta ugu yar ee diidmada.
• Daawadu waxay ku fiican yihiin kordhinta isgaadhsiinta unugyada iyo bilaabista hagaajinta marka lagu daro ilo kale oo daawaynta allogeneic ah sida dareeraha amniotic ama Wharton's Jelly.

Doorashada taas oo daaweynta bayoolojiga dabiiciga ah waa kan ugu fiican waa ka duwan yahay qof kasta. Marka la dooranayo daawaynta, waxaa lama huraan u ah shakhsiyaadka inay la tashadaan bixiyehooda daryeelka caafimaadka aasaasiga ah si ay u go'aamiyaan arjiga natiijooyinka ugu wanaagsan.

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Mooshinku ma fure u yahay bogsiinta?

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tixraacyada

Aly RM (2020). Xaaladda hadda ee daaweynta unugyada stem-ku-saleysan: dulmar. Baaritaanka unugyada stem, 7, 8. doi.org/10.21037/sci-2020-001

Machadyada Caafimaadka Qaranka. (2016). Aasaaska Unugyada stem.

Qian, Y., Han, Q., Chen, W., Song, J., Zhao, X., Ouyang, Y., Yuan, W., & Fan, C. (2017). Platelet-Rich Plasma Waxyaalaha Kobaca ee Laga Soo Saaray Waxay Wax Ka Taraan Kaladuwanaanshaha Unugyada Jirka ee Dib-u-soo-noolaynta Muruqyada. Xuduudaha kimisteriga, 5, 89. doi.org/10.3389/fchem.2017.00089

Bulshada Kansarka Maraykanka. (2023). Noocyada Unugyada stem iyo Dhuuxa Lafaha.

Mazini, L., Rochette, L., Admou, B., Amal, S., & Malka, G. (2020). Rajada iyo Xadka Unugyada Jirka ee Adipose-Derived (ADSCs) iyo Unugyada stem Mesenchymal (MSCs) ee Bogsiinta Dhaawaca. Joornaalka caalamiga ah ee cilmiga molecular, 21(4), 1306. doi.org/10.3390/ijms21041306

Klemmt P. (2012). Codsiga unugyada tarma ee dareeraha amniotic ee sayniska aasaasiga ah iyo dib u soo noolaynta unugyada. Organogenesis, 8 (3), 76. doi.org/10.4161/org.23023

Sabapathy, V., Sundaram, B., VM, S., Mankuzhy, P., & Kumar, S. (2014). Human Wharton's Jelly Mesenchymal Stem Cells balaastikada waxay kordhisaa bogsashada nabarka maqaarka ee aan nabar lahayn ee koritaanka timaha. PloS kow, 9 (4), e93726. doi.org/10.1371/journal.pone.0093726

Gao, F., Chiu, SM, Motan, DA, Zhang, Z., Chen, L., Ji, HL, Tse, HF, Fu, QL, & Lian, Q. (2016). Unugyada stem Mesenchymal iyo immunomodulation: heerka hadda iyo rajada mustaqbalka. Dhimashada unugyada & cudurka, 7(1), e2062. doi.org/10.1038/cddis.2015.327

Harrell, CR, Jovicic, N., Djonov, V., Arsenijevic, N., & Volarevic, V. (2019). Unugyada Jirka ee Mesenchymal-Derived Exosomes iyo unugyo kale oo ka baxsan unugyada sida dawooyin cusub oo lagu daweeyo cudurrada bararka. Unugyada, 8 (12), 1605. doi.org/10.3390/cells8121605