Sahaminta Daaweynta Dib-u-soo-noolaynta Thyroid

Marka cilmi-baaristu ay korodho daawada dib-u-soo-nooleynta leh ee suurtogalka ah ee awood u leh inay dib u koraan unugyada tayroodh, daawaynta dib-u-soo-nooleynta ayaa baabi'in karta baahida bukaanka si ay u qaataan hormoonnada beddelka tayroodhka?

Daaweynta Dib-u-soo-celinta Qanjirka thyroid

Rajo weyn oo ku saabsan daaweynta dib-u-soo-nooleynta waa awoodda koritaanka caafimaad xubnaha. Mid ka mid ah xubnaha la eegayo waa qanjirka thyroid. Hadafku waa in dib loo kobciyo unugyada tayroodh ee:

• Shakhsiyaadka ay ahayd in laga saaro qanjirka sababtoo ah kansarka tayroodh.
• Shakhsiyaadka ku dhashay iyada oo aan lahayn qanjir si buuxda u horumarsan.

Sida cilmi-baarista sayniska iyo cilmi-baaristu ay ka ballaariyeen tijaabooyinka shaybaarka iyo xayawaanka si ay u tijaabiyaan tuubada tayroodhka unugyada tayroodh ee bini'aadamka, isticmaalka daaweynta unugyada stem-ka ee ujeedadan weli ma jiro, sababtoo ah cilmi-baaris ballaaran ayaa loo baahan yahay tixgelinta aadanaha.

Cilmi-baarista Aadanaha

Cilmi-baaris ku saabsan isticmaalka daaweynta dib-u-soo-celinta tayroodhka ee cudurka thyroid-ka ma daabacin daraasado kaas oo daaweynta unugyada stem lagu tijaabiyay bukaannada tayroodh ee bini'aadamka.

• Daraasadaha la sameeyay ayaa lagu sameeyay jiirar, wax kasta oo ka soo baxa cilmi-baaristan si toos ah looguma dabaqi karo aadanaha. (HP Gaide Chevronnay, iyo al., 2016)
• Unugyada qanjirka tayroodhka ee bini'aadamka ee daraasadaha tuubada tijaabada, kicinta unugyada ayaa lagu gaaray hab kor u qaaday su'aasha ah samaynta isbeddelka kansarka ee suurtogalka ah haddii la isku dayo in bini'aadamka. (Davies TF, iyo al., 2011)

Daraasadihii ugu dambeeyay

• Cilmi-baarista hadda waxay ku lug leedahay horumarka laga sameeyay Unugyada stem embriyaha - ESC iyo unugga tarma ee pluripotent induced – iPSC. (Will Sewell, Reigh-Yi Lin. 2014)
• ESCs, oo sidoo kale loo yaqaanno unugyada asliga ah ee pluripotent, waxay kordhin karaan nooc kasta oo unugyada jirka ah.
• Waxay ka soo go'aan embriyaha la soo saaray, laakiin aan la gelin, inta lagu jiro hababka IVF.
• iPSCs waa unugyo badan oo awood badan kuwaas oo la sameeyay iyadoo la adeegsanayo habka dib u habeynta unugyada qaangaarka.

1. Unugyada follicular waa unugyo tayroodh oo sameeya hoormoonnada tayroodhka - T4 iyo T3 waxaana laga soo saaray unugyada tarma ee embriyaha ee jiirarka.
2. Daraasad lagu daabacay joornaalka Cell Stem Cell ee 2015, unugyadani waxay awood u leeyihiin inay koraan waxayna sidoo kale awoodeen inay bilaabaan inay sameeyaan hormoonka tayroodh laba toddobaad gudahood. (Anita A. Kurmann, iyo al., 2015)
3. Siddeed usbuuc ka dib, unugyo lagu tallaalay jiirar aan lahayn qanjidhada tayroodh waxay lahaayeen xaddi caadi ah oo hoormoon tayroodh ah.

Qanjirka Thyroid-ka Cusub

• Baarayaasha Cusbitaalka Mount Sinai waxay u horseedeen unugyada stem embriyaha bini'aadamka ee unugyada tayroodhka.
• Waxay eegayeen suurtagalnimada abuurista qanjidhada tayroodh cusub oo u eg shakhsiyaadka qalliinka laga saaray qanjidhkooda.
• Waxay ka warbixiyeen natiijooyinkooda shirkii 84-aad ee Ururka Thyroid Association ee Maraykanka. (R. Michael Tuttle, Fredric E. Wondisford. 2014)

Mustaqbalku wuxuu u muuqdaa mid rajo leh awoodda dib u kobcinta unugyada tayroodh iyo baabi'inta hoormoonka beddelka tayroodhka. Si kastaba ha ahaatee, cilmi-baaris aad u badan ayaa loo baahan yahay si tan xitaa loogu tixgeliyo suurtogalnimada.

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Dildilaaca Hagaha Qiimaynta Xeerka Thyroid Low

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tixraacyada

Gaide Chevronnay, HP, Janssens, V., Van Der Smissen, P., Rocca, CJ, Liao, XH, Refetoff, S., Pierreux, CE, Cherqui, S., & Courtoy, PJ (2016). Ku-tallaalidda Unugyada Jirka Hematopoietic waxay caadi ka dhigi karaan Shaqada Thyroid Model Cystinosis Mouse. Endocrinology, 157(4), 1363-1371. doi.org/10.1210/en.2015-1762

Davies, TF, Latif, R., Minsky, NC, & Ma, R. (2011). Dib-u-eegis bukaan-socod: Bayoloji unugga soo baxaya ee unugyada stem tayroodh. Joornaalka endocrinology kiliinikada iyo dheef-shiid kiimikaadka, 96(9), 2692-2702. doi.org/10.1210/jc.2011-1047

Sewell, W., & Lin, RY (2014). Jiilka unugyada follicular tayroodh ee unugyada asliga ah ee pluripotent: suurtagalnimada daawada dib u soo kabashada. Xuduudaha endocrinology, 5, 96. doi.org/10.3389/fendo.2014.00096

Kurmann, AA, Serra, M., Hawkins, F., Rankin, SA, Mori, M., Astapova, I., Ullas, S., Lin, S., Bilodeau, M., Rossant, J., Jean, JC, Ikonomou, L., Deterding, RR, Shannon, JM, Zorn, AM, Hollenberg, AN, & Kotton, DN (2015). Dib-u-soo-nooleynta Shaqada Thyroid-ka iyadoo la beddelayo Unugyada Jirka Pluripotent ee Kala Duwan. Unugga asliga ee unugga, 17(5), 527-542. doi.org/10.1016/j.stem.2015.09.004

Tuttle, RM, & Wondisford, FE (2014). Ku soo dhawaada shirkii 84-aad ee Ururka Thyroid Association. Thyroid: joornaalka rasmiga ah ee Ururka Thyroid American, 24(10), 1439-1440. doi.org/10.1089/thy.2014.0429