Biochemistry ee Methylation DNA

Hordhac Methylation

Methylation, oo sidoo kale loo yaqaan dheef-shiid kiimikaad-kaarboon ah, waa geeddi-socod biochemical ah oo kiciya dhaqdhaqaaqa methylation. Kooxda methyl, oo ka mid ah unugyada ugu caansan ee iskudhisyada organic, waxay ka samaysan yihiin hal atom oo kaarboon ah oo ku xidhan saddex atamka hydrogen (-CH3). Kooxda methyl, oo lagu daray ama laga saaray borotiinnada ama asiidhka nucleic, guud ahaan waxaa loo abuuri karaa laba siyaabood oo kala duwan, oo ay ku jiraan:

1. Ku-xidhka atamka hydrogen-ka ah ee atamka methylene (-CH2-), waxay kor u qaadaa soo saarista enzyme methylenetetrahydrofolate reductase, ama MTHFR. Alaabta falcelintan waxaa loo yaqaan 5-methylTHF.
2. Isbeddelka kooxda methyl, sida catechol-O-methyltransferase, oo sidoo kale loo yaqaan COMT, iyo DNA methyltransferase, oo sidoo kale loo yaqaanno DNMT enzymes. DNA methyltransferase enzymes waxay isticmaalaan kooxaha methyl ee firfircoon ee S-adenosylmethionine ama SAME.

SAME waxa uu isu beddelaa S-adenosyl homocysteine, ama SAH, ka dibna homocysteine ​​waxa lagu muujiyey Jaantuska 1. Homocysteine ​​waxa kale oo uu u beddeli karaa methionine iyada oo loo marayo mid ka mid ah laba waddo oo kala duwan. Waddada ugu weyn, iyada oo loo marayo beddelka methionine synthase, waxay u baahan tahay beddelka koox methyl ah oo ka socota 5-methyltetrahydrofolate, ama 5-mTHF, halkaas oo ay ku abuurto enzyme methylenetetrahydrofolate reductase, ama MTHFR, enzyme ugu caansan ee waddooyinka dheef-shiid kiimikaadka folate. .

Dariiqa labaad ee biosynthesis ee methionine ee ka yimaada homocysteine ​​waa iyada oo loo marayo betaine homocysteine ​​​​methyltransferase, taas oo ku dhacda beerka iyo kelyaha. Homocysteine ​​​​waxaa kale oo laga yaabaa inuu kiciyo dariiqa kiimikaad kale, gaar ahaan inta lagu jiro xaaladaha walaaca oksaydhiyaha ee kordhay, kaas oo u beddela homocysteine ​​​​ee cystathionine ilaa taurine, glutathione, ama sulfate. Dariiqa transsulfured waa mid joogto ah, si kastaba ha ahaatee, si loo soo saaro glutathione, homocysteine ​​​​waxaa laga yaabaa in loo isticmaalo si loo dhaliyo SAME, iyo wadooyin kale.

Folate-ka cuntada waxaa laga heli karaa noocyo kala duwan oo cunto ah sida walxaha loo yaqaan pteropolyglutamates. Si loo nuugo si wax ku ool ah, polyglutamate-ka waxaa lagu shubaa xiidmaha mindhicirrada monoglutamate oo loo yaqaan tetrahydrofolate ama THF. Folic acid, dhinaca kale, qaabka ugu caansan ee loo yaqaan 'synthetic form' ee nafaqeynta ee lagu isticmaalo xoojinta cuntada, waa in la dhimo enzyme dihydrofolate reductase, ama DHFR, laba jeer beerka halkaas oo ay u baahan doonto in lagu daro laba atom oo hydrogen ka hor. waxay isu rogi kartaa THF.

Inta badan, hawsha DHFR inta badan way kala duwanaan kartaa waxaana laga yaabaa inay ugu dambeyntii hoos u dhacdo. Dhaqdhaqaaqa DHFR ee beerka ayaa sidoo kale 56 jeer ka hooseeya bini'aadamka, sida laga soo xigtay cilmi-baarisyada cilmi-baarista, taas oo macnaheedu yahay in aan ka taxaddarno marka aan turjumeyno qiyaasta natiijada farmashiyaha ee folic acid ee xayawaanka. Marar badan, takhaatiirta iyo daaweeyayaasha shaqada waxay isticmaali doonaan noocyo kale oo folates dheeri ah oo ay ku jiraan 5-mTHF iyo folinic acid, ama 10-formyl THF, si looga fogaado xannibaadda DHFR ee suurtagalka ah, iyo xaaladda 5-mTHF, iyada oo ujeedadu tahay in laga hortago polymorphism. xannibaadyada MTHFR enzyme. Daraasado badan oo cilmi baaris ah ayaa muujiyay natiijooyinkan.

Daraasadaha cilmi-baarista ee isbarbardhigga saameynta 5-mTHF iyo folic acid ee folate ayaa muujiyay in methylation ay sidoo kale waxtar u yeelan karto kor u qaadista heerarka folate. Folinic acid ayaa mararka qaarkood loo adeegsadaa in lagu taageero heerarka folate-ka maskaxda ee xaaladaha qaarkood halkaas oo unugyada difaaca jirka ay u qaadaan folate-ka borotiinada ee xannibaadda dhiigga-maskaxda. Fahamka biochemistry ee methylation waa kaliya hordhaca methylation. Nafaqada iyo wax ka beddelka qaab nololeedka ayaa la soo bandhigay si looga caawiyo taageerada methylation.

Methylation, wareejinta kooxda methyl ee xarun organic, waxaa loo qaybin karaa laba nooc oo asaasi ah: kiimiko iyo bayooloji. Nidaaminta methylation ee jidhka bini'aadamka waxaa lagu hormariyaa iyada oo loo marayo isbeddelka DNA-da iyo borotiinnada ama enzymes. Ujeedada maqaalkan soo socda waa in la muujiyo sida kiimikooyinka iyo walxaha bayoolojiga ay door uga ciyaaraan nidaaminta methylation DNA. Fahamka hababkan ayaa muhiim u ah hagaajinta caafimaadka guud ee bukaanka iyo fayoobaanta.

Dr. Alex Jimenez DC, CCST Insight

Smoothies iyo Casiirka ee Taageerada Methylation

Iyadoo xirfadlayaal badan oo daryeel caafimaad ay ku talinayaan hab-nololeedyo hab-nololeed iyo hab-nololeedka wax lagaga beddelo, waxa jira dhawr ikhtiyaar oo daawayn oo kale oo aad isku dayi karto naftaada gurigaaga. Sida kor lagu sharaxay, si kastaba ha ahaatee, kaabista taageerada methylation waa in si sax ah loo go'aamiyaa xirfadle daryeel caafimaad. Smoothies iyo casiirka waa hab degdeg ah oo sahlan oo lagu daro dhammaan nafaqooyinka lagama maarmaanka ah ee aad u baahan tahay taageerada methylation ee hal adeeg. Maraqa iyo casiirka hoose waa qayb ka mid ah Qorshaha Cuntada Methylation.

Smoothie Cagaaran Badda
Adeegyada: 1
Wakhtiga la karinayo: daqiiqadaha 5-10
1/2 koob oo cantaloupe ah, la jarjarey
� 1/2 muus
� 1 cantoobo ah oo kale ama isbinaaj
� 1 muggeed oo chard Swiss ah
1/4 avokado
� 2 qaado oo budada spirulina ah
1 cup biyaha
3 ama in ka badan oo baraf ah
Isku qas dhammaan maaddooyinka ku jira blender-xawaaraha sare leh ilaa si buuxda u siman oo ku raaxayso!

Berry Bliss Smoothie
Adeegyada: 1
Wakhtiga la karinayo: daqiiqadaha 5-10
1/2 koob blueberries (cusub ama la qaboojiyey, gaar ahaan duurjoogta)
� 1 karooto dhexdhexaad ah, qiyaas ahaan la jarjaray
1 qaado oo ah iniinaha flaxseed ama iniin chia
� 1 qaado oo yicib ah
� Biyo (ilaa is waafajin la rabo)
� xabadaha barafka (ikhtiyaar, waa laga tagi karaa haddii la isticmaalo blueberries barafaysan)
Isku qas dhammaan maaddooyinka ku jira blender-xawaaraha sare leh ilaa ay siman yihiin oo labeen Sida ugu fiican isla markiiba loo adeego!

Sweet iyo Casiirka basbaaska leh
Adeegyada: 1
Wakhtiga la karinayo: daqiiqadaha 5-10
� 1 koob oo qaraha malabka ah
3 koob oo isbinaajka ah, oo la dhaqay
3 koob oo chard Swiss ah, oo la dhaqay
1 farabadan oo cilantro ah (caleemo iyo afkoda), la dhaqay
1-inch buro oo sinjibiil ah, la luqluqsaday, diiray oo la jarjaray
2-3 buro oo rooti dhanaan ah (ikhtiyaar), waa la dhaqay, diiray oo la jarjaray
Casiir dhammaan maaddooyinka ku jira casiirka tayada sare leh. Sida ugu fiican isla markiiba loo adeego!

Casiirka Cagaarka Sanjabiisha
Adeegyada: 1
Wakhtiga la karinayo: daqiiqadaha 5-10
� 1 koob oo xabadaha cananaaska
1 tufaax, jarjaran
1-inch buro oo sinjibiil ah, la luqluqsaday, diiray oo la jarjaray
� 3 koob oo kale, la raaci oo qiyaas ahaan la jarjaray ama jeexjeexay
5 koob oo chard Swiss ah, la dhaqay oo qiyaas ahaan la jarjaray ama la jeexjeexay
Casiir dhammaan maaddooyinka ku jira casiirka tayada sare leh. Sida ugu fiican isla markiiba loo adeego!

Casiirka dabocase ee Zesty
Adeegyada: 1
Wakhtiga la karinayo: daqiiqadaha 5-10
� 1 canab, diiray oo la jarjaray
� 1 tufaax, la dhaqay oo la jarjaray
� 1 dabocase oo dhan, iyo caleemo haddii aad haysatid, dhaq oo jarjar
1-inch buro oo sinjibiil ah, la luqluqsaday, diiray oo la jarjaray
Casiir dhammaan maaddooyinka ku jira casiirka tayada sare leh. Sida ugu fiican isla markiiba loo adeego!

Protein Power Smoothie
U adeega: 1
Waqtiga la kariyo: daqiiqado 5
� 1 qaado oo budada borotiinka ah
� 1 qaado oo flaxseed dhulka ah
� 1/2 muus
1 kiwi, diiray
� 1/2 qaado shaah qorfe ah
� qanjaruufo xabo
� Caano ama biyo aan caano ahayn, oo ku filan si loo gaaro joogteynta la rabo
Isku qas dhammaan maaddooyinka ku jira blender awood sare leh ilaa ay si buuxda u siman yihiin. Sida ugu fiican isla markiiba loo adeego!

ProLon

Taageerada methylation-ka ee dheellitiran waxaa lagu gaari karaa nafaqo habboon. ProLon. Barnaamijka cuntadu waxa uu ka kooban yahay diyaar u ah in la cuno ama si fudud loo diyaariyo, cuntooyinka dhirta ku salaysan, oo ay ku jiraan baararka, maraqyada, cunto fudud, kaabayaasha, cabitaanka xooga saaraysa, iyo shaaha. Alaabooyinka si cilmiyeysan ayaa loo qaabeeyey oo dhadhan fiican leh. Kahor intaadan bilaabin ProLon� cunto ku dayasho soonka, barnaamijka cuntada 5-maalmood, fadlan hubi inaad la hadasho xirfadle daryeel caafimaad si aad u ogaato haddii FMD ay kugu habboon tahay. ProLon� cunnada isku dayashada soonka waxay gacan ka geysan kartaa kor u qaadida taageerada methylation, oo ay ka mid yihiin noocyo kale oo kala duwan caafimaad faa'iidooyinka.

Dhakhaatiir badan iyo dhakhaatiirta shaqada ee daawada ayaa laga yaabaa inay kugula taliyaan qiyaaso badan oo deeq-bixiyeyaasha methyl ah ee bukaanno badan, si kastaba ha ahaatee, daraasado cilmi baaris oo dheeraad ah ayaa loo baahan yahay si loo go'aamiyo qadarka saxda ah ee dheellitirka methylation. Baaxadda macluumaadkayagu waxay ku xaddidan tahay xanuunka loo yaqaan 'chiropractic, murqaha' iyo arrimaha caafimaadka neerfaha iyo sidoo kale maqaallada daawada shaqeynaya, mowduucyada, iyo doodaha. Si aad uga hadasho mawduuca kor ku xusan, fadlan xor u noqo inaad weydiiso Dr. Alex Jimenez ama nala soo xiriir 915-850-0900 .

Waxaa soo saaray Dr. Alex Jimenez

Dood Mawduuc Dheeraad ah: Xanuun Dhabar Ba'an

Xanuunka dhabarka waa mid ka mid ah sababaha ugu badan ee naafanimada iyo maalmaha shaqada laga waayo adduunka oo dhan. Dhabar xanuunka waxa loo aaneynayaa sababta labaad ee ugu badan ee booqashooyinka xafiiska dhakhtarka, oo ay ka badan yihiin kaliya caabuqyada neef-mareenka sare. Qiyaastii 80 boqolkiiba dadku waxay la kulmi doonaan xanuunka dhabarka ugu yaraan hal mar noloshooda oo dhan. Laf-dhabartaadu waa qaab-dhismeed kakan oo ka kooban lafo, kala-goysyo, seedaha, iyo murqaha, iyo unugyo kale oo jilicsan. Dhaawacyada iyo/ama xaaladaha sii xumeeyay, sida maqaarka herniated, ugu dambeyntii waxay keeni kartaa calaamadaha xanuunka dhabarka. Dhaawacyada isboortiga ama dhaawacyada shilalka baabuurta ayaa inta badan ah sababta ugu badan ee xanuunka dhabarka, si kastaba ha ahaatee, mararka qaarkood dhaqdhaqaaqa ugu fudud ayaa keeni kara natiijooyin xanuun leh. Nasiib wanaag, xulashooyinka daaweynta kale, sida daryeelka xanuunka loo yaqaan 'chiropractic care', ayaa kaa caawin kara yareynta xanuunka dhabarka iyada oo loo marayo isticmaalka isbeddelka laf-dhabarka iyo manfacyada gacanta, ugu dambeyntii hagaajinta xanuunka.

Foomamka Taageerada Methylation

XYMOGEN Foomamka Xirfadlayaasha Gaarka ah ayaa la heli karaa iyada oo loo marayo xulashada xirfadlayaasha daryeelka caafimaadka shatiga. Iibinta intarneedka iyo qiimo dhimista hababka XYMOGEN waa mamnuuc.

Ku faan Dr. Alexander Jimenez waxay ka dhigaysaa qaaciidooyinka XYMOGEN inay helaan bukaannada ku hoos jira daryeelkayaga.

Fadlan wac xafiiskayaga si aanu kuugu meelayno la-talin dhakhtar si degdeg ah loo galo.

Hadii aad tahay bukaan Dhaawaca Caafimaadka & Rugaha Dhakhaatiirta, waxa aad wax ka waydiin kartaa XYMOGEN adiga oo waca 915-850-0900.

Si ay kuugu habboonaato iyo dib u eegistaada XYMOGEN alaabta fadlan dib u eeg xidhiidhka soo socda.*XYMOGEN-Catalog-Download

* Dhammaan siyaasadaha kor ku xusan ee XYMOGEN si adag ayay u shaqaynayaan.

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