Endocrinology functional: Caadiyan mindhicirka

Microbes waxay leeyihiin unugyo badan oo unugyo badan leh waxayna saameyn badan ku yeelan karaan caafimaadka iyo fayoqabka martida loo yahay. Cilmi-baarayaashu waxay sheegeen in microbes ay saameeyaan dheef-shiid kiimikaad, difaac, iyo habdhaqanka jidhka bini'aadamka. Mid ka mid ah hababka ugu muhiimsan laakiin aan la baran ee ay microbes leeyihiin waa in ay ku lug yeelan karaan hormoonnada. Joogitaanka microbiota mindhicirka, isbeddellada gaarka ah ee heerarka hoormoonka ayaa isku xiri kara mindhicirka. Microbiota mindhicirku waxay soo saari kartaa oo soo saari kartaa hormoonnada, waxay ka jawaabi kartaa hormoonnada martida loo yahay, waxayna nidaamin kartaa heerarka muujinta. Waxa kale oo jira xidhiidh ka dhexeeya nidaamka endocrine iyo microbiota mindhicirka maadaama macluumaad dheeraad ah weli la baarayo.

Xidhiidhka Gut to Hormone

Tan iyo markii ay microbiome-ka bini'aadamka ayaa ka kooban noocyo badan oo microbes ah iyo hiddo-sideyaal muujinaya kakanaanta sare. Si ka duwan xubnaha kale ee jirka, mindhicirka microbiota shaqadiisa si buuxda looma fahmin weli laakiin waxaa si fudud u carqaladayn kara antibiyootiga, cuntada, ama qaliinka. Shaqada ugu fiican ee lagu sifeeyay waa sida microbiota mindhicirku ula falgalo nidaamka endocrine ee jirka.

Cilmi baaris soo ifbaxday ayaa muujisay in microbiome-ka mindhicirku uu door dhexe ka ciyaaro nidaaminta heerarka estrogen ee jirka. Marka heerarka hoormoonka estrogen uu aad u sarreeyo ama aad u hooseeyo, waxay u horseedi kartaa khatarta ah inay yeeshaan cudurrada la xiriira estrogen sida endometriosis, polycystic ovary syndrome, kansarka naasaha, iyo kansarka qanjirka 'prostate' ee ragga iyo dumarka.

Xididdada iyo isku xirka hoormoonka waa lama huraan maadaama mindhicirku yahay mid ka mid ah soo saarayaasha si ay u abuuraan hormoono dhex mara nidaamka jidhka oo dhan. Iyada oo nidaamka endocrine uu ku lug leeyahay, waa shabakadii ugu horreysay ee soo saarta oo u qaada hormoonnada xubnaha u baahan hormoonnada si ay u shaqeeyaan. Marka ay jirto dheellitirnaan la'aanta hormoonnada jidhka bini'aadamka, waxay carqaladeyn kartaa dhammaan hormoonnada kale.

Microbiota mindhicirku wuxuu saameeyaa ku dhawaad ​​hormoon kasta oo habka endocrine uu abuuro, oo ay ku jiraan:

• Hormoonnada tayroodhka
• Hormoonnada Estrogen
• Hormoonnada cadaadiska

Hormoonnada Thyroid

Haddii mindhicirku leeyahay barar, markaa hormoonnada jidhku waxay abuuri doonaan xad-dhaaf ah ama tiro yar oo jidhka ah. Haddii qanjidhada endocrine sida thyroid, waa soo saarida tiro yar hormoonnada iyo mindhicirku waxay noqon karaan kuwo dheelli-tiran waxayna u horseedi karaan hypothyroidism. Marka ay jiraan kala duwanaansho microbial hoose ee mindhicirka, daraasad ayaa muujisay in kala duwanaanshaha microbial hoose uu ku xiran yahay TSH sare (hormoonka tayroodh-kicinta) heerarka. Tirada xad dhaafka ah ee hoormoonada tayroodh waxay keeni kartaa hyperthyroidism. Labaduba hyperthyroidism iyo hypothyroidism waxay keeni karaan calaamado ay ka mid yihiin xanaaq, walaac, xasuus xumo, iyo calaamado badan oo saameyn kara jirka.

"Haddii aad la kulanto xinjiro badan, daac, dibiro, saxaro adag oo adag oo ay ku adkaato dheefshiidka borotiinka iyo hilibka; cuntada aan dheefshiidka lahayn ee laga helo saxarada, dhibaatooyinka dheefshiidka ayaa ku yaraada nasashada iyo nasashada ama calaamad kasta. Markaa maqaalkani wuxuu ku siin doonaa inaad si fiican u fahamto waxa ku dhacaya mindhicirka iyo sida hormoonnada ay u saameyn karaan nidaamka mindhicirka.

Hormoonnada Estrogen

Mindhicirka iyo hormoonnada qofka ayaa loola jeedaa wada xidhiidh midba midka kale. Ma aha oo kaliya inay is taageeraan, laakiin sidoo kale waxay ka wada shaqeeyaan si loo hubiyo in jidhku si habsami leh u socdo. Daraasaduhu waxay ogaadeen in unugyada mindhicirrada mindhicirku ay leeyihiin reseptors gaar ah oo hormoonnada kuwaas oo u oggolaanaya inay ogaadaan wax kasta oo isbeddel hormoon ah oo saameeya jidhka.

Maadaama estrogen uu caadi ahaan xiriir la leeyahay haweenka, waa wax caadi ah in raggu u baahan yihiin qiyaasta saxda ah ee estrogen heerarka si ay u shaqeeyaan. Microbiota mindhicirku waa nidaamiyaha muhiimka ah ee heerka iyo wareegga wareegga estrogen ee jirka. Microbes-ku waxay soo saaraan enzim loo yaqaan beta-glucuronidase, kaas oo markaa u beddela hormoonka estrogen qaabkiisa firfircoon.

Microbiome-ka mindhicirka wuxuu nidaamin karaa heerarka estrogen isagoo ka shaqeynaya bakteeriya gaar ah oo ku jirta microbiome-ka loo yaqaan 'estrobolome'. Estrobolome waa isu geynta hiddo-wadaha bakteeriyada gasha kuwaas oo awood u leh inay dheef-shiidaan estrogen. Waxa laga yaabaa inay saamayso khatarta haweenka ee ah inuu ku dhaco kansarka naasaha ee soo-jiidhiyaha estrogen-positive postmenopausal. Estrobolome-ku aad ayuu lagama maarmaan u ah in lagu ilaaliyo heerarka estrogen ee jirka xaalad deggan.

Microbiota mindhicirka, labadaba hormoonnada estrogen iyo progesterone waxay saamayn kartaa dhaqdhaqaaqa mindhicirka iyo peristalsis (Dhaqdhaqaaqa laxanka ee xiidmaha ee cuntada u dhex mara caloosha iyo jidhka) iyagoo ka ciyaaraya door ka soo horjeeda dhaqdhaqaaqa mindhicirka. Progesterone waxay caawisaa hoos u dhigista dhaqdhaqaaqa mindhicirka iyadoo dejinaysa socodka siman oo gaabinaya wakhtiga cuntadu ka baxayso jidhka. Estrogen-ku wuxuu caawiyaa kordhinta foosha murqaha siman ee xiidmaha. Marka hormoonnada Estrogen-ka si sax ah loo simo, waxay kaa caawin kartaa in mindhicirku si habsami leh u socdo oo uu kordhiyo kala duwanaanshaha microbiomes jirka, taas oo wax u wanaagsan nidaamka difaaca.

Hormoonnada Cadaadiska

Hormoonnada cadaadiska ama cortisol ayaa qayb weyn ka ciyaara microbiota mindhicirka. Tan iyo markii hormoonnada cortisol ku xidhid maskaxda, waxay u dirtaa calaamadaha mindhicirka iyo lidkeeda. Haddi ay tahay walaac gaaban sida isu diyaarinta bandhig ama waraysi shaqo, qofku waxa uu mindhicirkiisa ku dareemi doonaa "balaalbaal". Cadaadiska dheer, tusaale ahaan, sida inaad haysato shaqo aad u dhib badan ama dareemo walaac joogto ah, waxay u horseedi kartaa jirro dabadheeraad ah oo ku jira mindhicirka sida caabuqa ama mindhicirka qulqulaya. Maadaama isku xirka hoormoonka iyo mindhicirku uu la mid yahay Xidhiidhka mindhicirka iyo maskaxda, Waa muhiim in hoos loo dhigo heerarka cortisol si ay u noqoto xaalad deggan si loo helo jir shaqeynaya oo caafimaad qaba.

Ugu Dambeyn

Xidhiidhka mindhicirka iyo hoormoonka ayaa macno qoto dheer leh maadaama ay si dhow isugu xidhan yihiin. Marka uu jiro khalkhal ku dhaca mindhicirka, waxay keeni kartaa hormoonnada inay dheellitirmaan, taasoo keenta khalkhal badan sida caabuqa iyo mindhicirka oo dillaaca. Marka uu jiro khalkhal ku yimaada hormoonnada, waxay carqaladayn kartaa mindhicirka iyo sidoo kale iyada oo si xun u beddelaysa microbiome-ka mindhicirka. Markaa si loo hubiyo in mindhicirku si sax ah u shaqeeyo, waxa muhiim ah in la cuno cunto ay ku jiraan probiotics oo la khamiiriyey si loo ilaaliyo caafimaadka flora mindhicirka. Alaabooyinka qaar ayaa kara miiska caawinta saamaynta dheef-shiid kiimikaadka ku-meel-gaadhka ah iyo taageeridda dheef-shiid kiimikaadka estrogen iyadoo lagu darayo nafaqooyinka kale ee muhiimka ah iyo cofactors si ay u taageeraan nidaamka endocrine.

Oktoobar waa bisha caafimaadka lafdhabarta. Si aad wax badan uga ogaato, hubi Bayaanka Guddoomiye Abbott shabakadayada si aad faahfaahin buuxda uga hesho wakhtigan taariikhiga ah.

Baaxadda macluumaadkayagu waxay ku xaddidan tahay xanuunka loo yaqaan 'chiropractic, murqaha' iyo arrimaha caafimaadka neerfaha iyo sidoo kale maqaallada daawada shaqeynaya, mowduucyada, iyo doodaha. Waxaan isticmaalnaa borotokool caafimaad oo shaqeynaya si aan u daaweyno dhaawacyada ama cilladaha daba dheeraada ee nidaamka muruqyada. Si aad uga hadasho mawduuca kor ku xusan, fadlan xor u noqo inaad weydiiso Dr. Alex Jimenez ama nala soo xiriir 915-850-0900 .

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