Silver wakiilka ka hortagga bakteeriyada

Ma dareemaysaa:

• Calool xanuun, gubasho, ama xanuun 1-4 saacadood ka dib cuntada?
• Xidid xad-dhaaf ah, daacasho, ama barar?
• Dhibaatooyinka dheefshiidka miyay hoos u dhacaan nasashada?
• Calool-baxa ka dib probiotics qaarkood?
• Isticmaalka joogtada ah ee daawada?

Haddii aad la kulanto mid ka mid ah xaaladahan, markaa waxaa laga yaabaa inaad la kulanto qaar ka mid ah dhibaatooyinka bakteeriyada habka difaaca jirka kuwaas oo hoos loogu dhigi karo wakiilka antimicrobial: silver.

Silver the Antimicrobial agent

Waxaa loo yaqaanaa inay tahay wakiilka antimicrobial ee qaabka boomaatada kareemka ee gubashada heerka labaad iyo saddexaad ee shakhsiyaadka. Silver ayaa loo raagay in loo isticmaalo sidii polymer cationic si loo soo saaro walxaha bakteeriyada waxaana lagu dabaqay biosensors, hababka gaarsiinta daroogada, iyo aaladaha caafimaadka ee u baahan guryaha antimicrobial.

Awoodda buuxda ee antimicrobial ee lacagta afka ayaan weli laga faa'iidaysanin inkasta oo cilmi-baadhistu ay leedahay qadar badan oo ballan-qaad ah isticmaalka lacagta. Cilmi-baadhistu waxay sheegtay Lacagtaas oo lagu yaqaanay wax ka qabashada dhibaatooyinka casriga ah ee xakamaynta caabuqa sida iska caabbinta dawooyinka badan, taas oo keenaysa tirada sii kordheysa ee cusbitaalka khatarta ah iyo caabuqyada ay bulshadu ka hesho shakhsiyaadka.

Si loo kordhiyo waxtarka antimicrobial ee lacagta jidhka ku jirta, waa in la wanaajiyaa iyada oo la nuugayo oo ay la falgasho xuubabka unugyada jidhka. Silver waa in lagu dhimo cabbirka u dhexeeya 1 iyo 100 nanometers (nm), kaas oo kala saaraya saamaynta daawaynta ee "nanoparticle silver."

Nanoparticles Silver

The nanoparticles lacag ah waa wakiilada bakteeriyada firfircoon ee jirka. Qodobbada muhiimka ah ee nanoparticles qalinka ah ayaa ah inay saameyn ku yeelan karaan dhaqdhaqaaqa bakteeriyada sababtoo ah cabbirkooda, qaabka, shaqada dusha sare, iyo xasilloonida. Astaamaha bakteeriyada bakteeriyada nanoparticles qalinka ayaa la ogaadaa inay korodho iyadoo hoos u dhac ku yimi dhexroorkooda, iyo is dhexgalka tooska ah ee nanoparticles qalinka ah ee bakteeriyada inta badan waxay dhacdaa marka dhexroorku uu yahay agagaarka 1-10 nm.

Marka nanoparticles lacagta ah lagu nuugo qulqulka dhiigga, ka dibna waxay ku dhegtaa oo ku ururtaa derbiyada unugyada bakteeriyada. Marka ay ku dhejiyaan derbiyada unugyada bakteeriyada, markaa way awoodaan keeni dhaawac aan laga noqosho lahayn iyada oo ku keenaysa isbeddel qaabdhismeed iyo qallafsanaan ku yimaadda gidaarada unugyada bakteeriyada iyada oo la abuurayo daldaloolo iyo kordhinta qulqulka. Baaxadda yar ee nanoparticles silver waa, awoodda sare ee ay u leedahay inay dhex gasho oo ay kordhiso noocyada bakteeriyada, kuwaas oo nanoparticles silver ay dili karaan.

Daraasado dhowr ah ayaa la muujiyay in dhaqdhaqaaqa nanoparticles silver uu si xoog leh ugu tiirsan yahay cabbirka. Tusaale ahaan, nanoparticles qalin ah oo ka yar 30 nm ayaa wax ku ool u ah lidka ku ah Staphylococcus aureus iyo Klebsiella pneumoniae. Bakteeriyada qalinka ah ma aha oo kaliya daciifinta derbiyada unugyada bakteeriyada (sida hababka ficilka ee antibiyootiga caadiga ah ee qaybaha penicillin iyo cephalosporin), laakiin marka ay gudaha galaan, waxay samayn karaan waxqabadyada bakteeriyada iyagoo waxyeelleynaya borotiinka iyo DNA-da iyada oo loo marayo denaturation iyo xannibidda qoraalka/tarjumaada. Ugu dambeyntii, nanoparticles lacag ah ayaa sii deyn kara ROS (noocyada oksijiinta falcelinta), taas oo kor u qaadeysa hawlihii hore ee bakteeriyada.

Nanoparticles Silver sida Antibiyootiga

Siyaabo badan, nanoparticles silver wuxuu u shaqeyn karaa sida antibiyootiga dhaqameed; si kastaba ha ahaatee, si ka duwan daawooyinka, nanoparticles silver ayaa wax ku ool u ah baaxadda ballaaran ee bakteeriyada Gram-positive iyo Gram-negative. Nanoparticles Silver ayaa aad waxtar ugu leh bakteeriyada Gram-negative, oo ka duwan antibiyootiga dhaqameed, waxay waxtar u leeyihiin marka ay burburiyaan fayraska iyo fungus. Daraasad 2019 ayaa lagu sheegay Nanoparticles qalin ah oo u dhexeeya 10 iyo 20nm ayaa la muujiyey inay leeyihiin xaddi badan oo ah ficil bakteeriyada lidka ku ah bakteeriyada sida Bacillus cereus, Listeria monocytogenes, Staphylococcus aureus, Staphylococcus saprophyticus, Escherichia coli, Pseudomonas putida. marka si fiican loo falanqeeyo lagu falanqeeyo.

Daraasad kale oo 2019 ah ayaa muujisay in nanoparticles silver ay waxtar u leeyihiin ciribtirka Gram-negative Pylori Helicobacter, kaas oo gumaysta epithelium gastric wuxuuna noqon karaa wakiilka sababa cudurrada caloosha iyo mindhicirka ee kala duwan sida boogaha peptic, gastritis, xuubka lymphoid lymphoma, iyo adenocarcinoma.

Maadaama caabbinta maandooriyaha badani ay tahay dhibaatada sii kordheysa ee daaweynta cudurrada faafa iyo isticmaalka baahsan ee antibiyootiga ballaaran ayaa la soo saaray sidii antibiyootiga iska caabbinta si ay uga ilaaliso noocyada bakteeriyada ka soo dhexgalka antibiyootiga. Si kastaba ha ahaatee, nasiib wanaag, nanoparticles silver ayaa la tusay ka hortagga sameynta glycocalyx taas oo lagama maarmaan u ah soo saarista biofilm, iyo nanoparticles silver ayaa awooday inay horumariyaan biofilms-ga oo ka hooseeya 50 g/mL.

Muujinta nanoparticles qalinka ah sida wakiilada bakteeriyada waa waxtarkooda ugu yar. Hal daraasad ayaa lagu sheegay in tan iyo lacagta si weyn loo isticmaalo codsiyada warshadaha sababtoo ah sifooyinka macdan iyo hawlaha bakteeriyada ay ka soo horjeedaan noole kala duwan. Sida koritaanka coli Escherichia, Staphylococcus, Providencia, seerraati, Iyo Pseudomonas aeruginosa waxaa xannibay joogitaanka lacagta qiyaasta qiyaas ahaan 1 �g/mL.

Tan iyo badbaadada nanoparticles lacag waa wanaagsan sida ay ku cilmi-baaris joogto ah mar haddii cytotoxicity lagu xusay xariiqyada unugyada qaarkood, falkanina uu yahay mid qiyaas-ku-tiirsanaan ah, iyo suntu waa ay yar tahay sidoo kalena ammaan u ah uruurinta ka yar 10 g/mL. Sida kaliya ee suurtogalka ah ee suntu ugu jirto jirka waa wax soo saarka xad-dhaafka ah ee ROS. Tirada xad dhaafka ah ee ROS waxay ku keeni kartaa diiqad oksaydh ah DNA, lipids, iyo borotiinada jidhka ku jira.

Ugu Dambeyn

Xilli ay caabuqyada bakteeriyadu aad u bateen oo ay korayaan si ay iskaga caabiyaan antibiyootiga. Waxyaalaha kale ee lidka ku ah bakteeriyada sida nanoparticles silver waa inay muhiim u yihiin jidhku si uu isu bogsiiyo. Inkasta oo nanoparticles qalinka ah aysan ahayn wakiilo cusub, waxay mudan yihiin in la siiyo ammaanta ay u qalmaan wax ka qabashada arrintan casriga ah ee caabuqa jirka. Oo ay la socdaan nanoparticles silver, qaar wax soo saarka waxaa loo yaqaanaa inay caawiyaan habka difaaca jirka oo ay bixiyaan nafaqooyinka hypoallergic, taageerada dheef-shiid kiimikaadka ee enzymes ee jirka, phytonutrients, bartilmaameedka amino acids, iyo bixinta taageerada caloosha iyo mindhicirka si uu jidhku si sax ah u shaqeeyo.

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Tixraacyo:

Franci, Gianluigi, iyo al. �Silver Nanoparticles oo ah wakiilada bakteeriyada ka hortaga ee suurtogalka ah.� Molecules (Basel, Switzerland), MDPI, 18ka Meey 2015, www.ncbi.nlm.nih.gov/pmc/articles/PMC6272636/.

Jose, Manu, iyo al. �Saamaynta Habka Diyaarinta Ku Saabsan Jirka Kiimikaad iyo Sifooyinka Ka-hortagga Bakteeriyada ee Titanate Nanotubes Oo Lagu Badalay Lacag.� Nanomaterials (Basel, Switzerland), MDPI, 23ka Meey 2019, www.ncbi.nlm.nih.gov/pmc/articles/PMC6566197/.

Nakamura, Shingo, iyo al. �Synthesis and Application of Silver Nanoparticles (Ag NPs) ee ka hortagga caabuqa ee shaqaalaha daryeelka caafimaadka.� Wargeyska Caalamiga ah ee Sayniska Molecular, MDPI, 24 Luulyo 2019, www.ncbi.nlm.nih.gov/pmc/articles/PMC6695748/.

Patil, Maheshkumar Prakash, iyo al. �Isbeddellada Moorfooloji ee Unugyada Bakteeriyada marka ay Soo Bandhigaan Qalab-Silver Chloride Nanoparticles La Sameeyey Isticmaalka Agrimonia Pilosa.� Cudurka Microbial Pathogenesis, Maktabadda Daawada Qaranka ee Maraykanka, Mar. 2018, www.ncbi.nlm.nih.gov/pubmed/29339306.

Saravanakumar, Kandasamy, iyo al. �Daah-furka Waxyaalaha ay leeyihiin Qaybaha Silver Nanoparticles ee Biocompatibility ee Unugyada Kansarka Sambabada ee A549 iyo Helicobacter Pylori. Warbixinno cilmi ah, Kooxda Daabacaada Dabeecadda UK, 8 Abril 2019, www.ncbi.nlm.nih.gov/pmc/articles/PMC6453883/.

Kooxda, DFH. �Silver as a Novel a Antibacterial agent.� Naqshadayaasha Caafimaadka, 22 Oktoobar 2019, blog.designsforhealth.com/node/1132.